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Trisha Nell Davis (born May 27, 1954) is an American biochemist, the current Earl Davie/ ZymoGenetics Chair of the department of biochemistry at the University of Washington. [1] Her early research focused on Calmodulin, though the primary focus of her lab has since shifted to the molecular machinery of cell division in budding yeast, especially the microtubule organizing centers and the kinetochores.

Background and education

Trisha Davis received her BA in Computer Science and Biology from the University of California, Santa Cruz in 1976. She received her Ph.D. in Molecular Biophysics and Biochemistry from Yale University in 1983. She joined the University of Washington Department of Biochemistry in 1997 and became acting chair of the department in 2011. In 2013, she became the first female chair of the Department.

Work and discoveries

Davis's post-doctoral research focused on Calmodulin in budding yeast [2] [3] After starting her own lab at the University of Washington, she discovered that Calmodulin performs an essential function in the yeast spindle pole body, [4] beginning the lab's gradual transition into the study of mitosis.

The Davis Lab has published extensively on the spindle pole body [5] [6] [7] [8] and on the kinetochore. [9] [10] [11] [12] Much of the recent research, conducted in collaboration with the Asbury Lab at the University of Washington, uses biophysical techniques such as optical tweezers to quantify the microtubule-coupling activity of the kinetochore.

Dr. Davis is also the director of the Yeast Resource Center (YRC), a Biomedical Technology Research Center supported by the National Institutes of Health and National Institute of General Medical Studies.

Awards and recognition

In 2020, Davis was named to the American Academy of Arts and Sciences. [13]

References

  1. ^ Advancement, UW Medicine. "Trisha N. Davis, Ph.D. - UW Medicine". Chairs & Professorships. Retrieved 2020-05-12.
  2. ^ Davis, Trisha N.; Urdea, Mickey S.; Masiarz, Frank R.; Thorner, Jeremy (1986). "Isolation of the yeast calmodulin gene: Calmodulin is an essential protein". Cell. 47 (3): 423–431. doi: 10.1016/0092-8674(86)90599-4. ISSN  0092-8674. PMID  3533275. S2CID  40739181.
  3. ^ Davis, T. N.; Thorner, J. (1989). "Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable". Proceedings of the National Academy of Sciences. 86 (20): 7909–7913. Bibcode: 1989PNAS...86.7909D. doi: 10.1073/pnas.86.20.7909. ISSN  0027-8424. PMC  298181. PMID  2554295.
  4. ^ Moser, M.J.; Flory, M.R.; Davis, T.N. (1997-08-01). "Calmodulin localizes to the spindle pole body of Schizosaccharomyces pombe and performs an essential function in chromosome segregation". Journal of Cell Science. 110 (15): 1805–1812. doi: 10.1242/jcs.110.15.1805. ISSN  0021-9533. PMID  9264467. Retrieved 2020-05-12.
  5. ^ Fong, Kimberly K.; Zelter, Alex; Graczyk, Beth; Hoyt, Jill M.; Riffle, Michael; Johnson, Richard; MacCoss, Michael J.; Davis, Trisha N. (2018-06-14). "Novel phosphorylation states of the yeast spindle pole body". Biology Open. 7 (10). The Company of Biologists: bio033647. doi: 10.1242/bio.033647. ISSN  2046-6390. PMC  6215409. PMID  29903865.
  6. ^ Viswanath, Shruthi; Bonomi, Massimiliano; Kim, Seung Joong; Klenchin, Vadim A.; Taylor, Keenan C.; Yabut, King C.; Umbreit, Neil T.; Van Epps, Heather A.; Meehl, Janet; Jones, Michele H.; Russel, Daniel; Velazquez-Muriel, Javier A.; Winey, Mark; Rayment, Ivan; Davis, Trisha N.; Sali, Andrej; Muller, Eric G. (2017-11-07). Bloom, Kerry S. (ed.). "The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling". Molecular Biology of the Cell. 28 (23). American Society for Cell Biology (ASCB): 3298–3314. doi: 10.1091/mbc.e17-06-0397. ISSN  1059-1524. PMC  5687031. PMID  28814505.
  7. ^ Fong, Kimberly K.; Sarangapani, Krishna K.; Yusko, Erik C.; Riffle, Michael; Llauró, Aida; Graczyk, Beth; Davis, Trisha N.; Asbury, Charles L. (2017-07-07). Bloom, Kerry S. (ed.). "Direct measurement of the strength of microtubule attachment to yeast centrosomes". Molecular Biology of the Cell. 28 (14). American Society for Cell Biology (ASCB): 1853–1861. doi: 10.1091/mbc.e17-01-0034. ISSN  1059-1524. PMC  5541836. PMID  28331072.
  8. ^ Lyon, Andrew S.; Morin, Geneviève; Moritz, Michelle; Yabut, King Clyde B.; Vojnar, Tamira; Zelter, Alex; Muller, Eric; Davis, Trisha N.; Agard, David A. (2016-07-15). Doxsey, Stephen (ed.). "Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly". Molecular Biology of the Cell. 27 (14). American Society for Cell Biology (ASCB): 2245–2258. doi: 10.1091/mbc.e16-02-0072. ISSN  1059-1524. PMC  4945142. PMID  27226487.
  9. ^ Scarborough, Emily Anne; Davis, Trisha N; Asbury, Charles L (2019-05-02). "Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules". eLife. 8. eLife Sciences Publications, Ltd. doi: 10.7554/elife.44489. ISSN  2050-084X. PMC  6516834. PMID  31045495.
  10. ^ Kim, Jae ook; Zelter, Alex; Umbreit, Neil T; Bollozos, Athena; Riffle, Michael; Johnson, Richard; MacCoss, Michael J; Asbury, Charles L; Davis, Trisha N (2017-02-13). "The Ndc80 complex bridges two Dam1 complex rings". eLife. 6. eLife Sciences Publications, Ltd. doi: 10.7554/elife.21069. ISSN  2050-084X. PMC  5354518. PMID  28191870.
  11. ^ Zelter, Alex; Bonomi, Massimiliano; Kim, Jae ook; Umbreit, Neil T.; Hoopmann, Michael R.; Johnson, Richard; Riffle, Michael; Jaschob, Daniel; MacCoss, Michael J.; Moritz, Robert L.; Davis, Trisha N. (2015-11-12). "The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling". Nature Communications. 6 (1). Springer Science and Business Media LLC: 8673. Bibcode: 2015NatCo...6.8673Z. doi: 10.1038/ncomms9673. ISSN  2041-1723. PMC  4660060. PMID  26560693.
  12. ^ Powers, Andrew F.; Franck, Andrew D.; Gestaut, Daniel R.; Cooper, Jeremy; Gracyzk, Beth; Wei, Ronnie R.; Wordeman, Linda; Davis, Trisha N.; Asbury, Charles L. (2009). "The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion". Cell. 136 (5). Elsevier BV: 865–875. doi: 10.1016/j.cell.2008.12.045. ISSN  0092-8674. PMC  2749323. PMID  19269365.
  13. ^ "UW president, biochemistry chair and mathematics professor named to American Academy of Arts and Sciences". UW News. 2020-04-23. Retrieved 2020-05-12.