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American biochemist
Trisha Nell Davis (born May 27, 1954) is an American
biochemist , the current
Earl Davie /
ZymoGenetics Chair of the department of biochemistry at the
University of Washington .
[1] Her early research focused on
Calmodulin , though the primary focus of her lab has since shifted to the molecular machinery of cell division in
budding yeast , especially the
microtubule organizing centers and the
kinetochores .
Background and education
Trisha Davis received her BA in Computer Science and Biology from the
University of California, Santa Cruz in 1976. She received her Ph.D. in Molecular Biophysics and Biochemistry from
Yale University in 1983. She joined the University of Washington Department of Biochemistry in 1997 and became acting chair of the department in 2011. In 2013, she became the first female chair of the Department.
Work and discoveries
Davis's post-doctoral research focused on
Calmodulin in budding yeast
[2]
[3]
After starting her own lab at the University of Washington, she discovered that
Calmodulin performs an essential function in the yeast
spindle pole body ,
[4] beginning the lab's gradual transition into the study of
mitosis .
The Davis Lab has published extensively on the spindle pole body
[5]
[6]
[7]
[8] and on the
kinetochore .
[9]
[10]
[11]
[12] Much of the recent research, conducted in collaboration with the Asbury Lab at the University of Washington, uses biophysical techniques such as
optical tweezers to quantify the microtubule-coupling activity of the kinetochore.
Dr. Davis is also the director of the Yeast Resource Center (YRC), a Biomedical Technology Research Center supported by the
National Institutes of Health and National Institute of General Medical Studies.
Awards and recognition
In 2020, Davis was named to the
American Academy of Arts and Sciences .
[13]
References
^ Advancement, UW Medicine.
"Trisha N. Davis, Ph.D. - UW Medicine" . Chairs & Professorships . Retrieved 2020-05-12 .
^ Davis, Trisha N.; Urdea, Mickey S.; Masiarz, Frank R.; Thorner, Jeremy (1986). "Isolation of the yeast calmodulin gene: Calmodulin is an essential protein". Cell . 47 (3): 423–431.
doi :
10.1016/0092-8674(86)90599-4 .
ISSN
0092-8674 .
PMID
3533275 .
S2CID
40739181 .
^ Davis, T. N.; Thorner, J. (1989).
"Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable" . Proceedings of the National Academy of Sciences . 86 (20): 7909–7913.
Bibcode :
1989PNAS...86.7909D .
doi :
10.1073/pnas.86.20.7909 .
ISSN
0027-8424 .
PMC
298181 .
PMID
2554295 .
^ Moser, M.J.; Flory, M.R.; Davis, T.N. (1997-08-01).
"Calmodulin localizes to the spindle pole body of Schizosaccharomyces pombe and performs an essential function in chromosome segregation" . Journal of Cell Science . 110 (15): 1805–1812.
doi :
10.1242/jcs.110.15.1805 .
ISSN
0021-9533 .
PMID
9264467 . Retrieved 2020-05-12 .
^ Fong, Kimberly K.; Zelter, Alex; Graczyk, Beth; Hoyt, Jill M.; Riffle, Michael; Johnson, Richard; MacCoss, Michael J.; Davis, Trisha N. (2018-06-14).
"Novel phosphorylation states of the yeast spindle pole body" . Biology Open . 7 (10). The Company of Biologists: bio033647.
doi :
10.1242/bio.033647 .
ISSN
2046-6390 .
PMC
6215409 .
PMID
29903865 .
^ Viswanath, Shruthi; Bonomi, Massimiliano; Kim, Seung Joong; Klenchin, Vadim A.; Taylor, Keenan C.; Yabut, King C.; Umbreit, Neil T.; Van Epps, Heather A.; Meehl, Janet; Jones, Michele H.; Russel, Daniel; Velazquez-Muriel, Javier A.; Winey, Mark;
Rayment, Ivan ; Davis, Trisha N.; Sali, Andrej; Muller, Eric G. (2017-11-07). Bloom, Kerry S. (ed.).
"The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling" . Molecular Biology of the Cell . 28 (23). American Society for Cell Biology (ASCB): 3298–3314.
doi :
10.1091/mbc.e17-06-0397 .
ISSN
1059-1524 .
PMC
5687031 .
PMID
28814505 .
^ Fong, Kimberly K.; Sarangapani, Krishna K.; Yusko, Erik C.; Riffle, Michael; Llauró, Aida; Graczyk, Beth; Davis, Trisha N.; Asbury, Charles L. (2017-07-07). Bloom, Kerry S. (ed.).
"Direct measurement of the strength of microtubule attachment to yeast centrosomes" . Molecular Biology of the Cell . 28 (14). American Society for Cell Biology (ASCB): 1853–1861.
doi :
10.1091/mbc.e17-01-0034 .
ISSN
1059-1524 .
PMC
5541836 .
PMID
28331072 .
^ Lyon, Andrew S.; Morin, Geneviève; Moritz, Michelle; Yabut, King Clyde B.; Vojnar, Tamira; Zelter, Alex; Muller, Eric; Davis, Trisha N.; Agard, David A. (2016-07-15). Doxsey, Stephen (ed.).
"Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly" . Molecular Biology of the Cell . 27 (14). American Society for Cell Biology (ASCB): 2245–2258.
doi :
10.1091/mbc.e16-02-0072 .
ISSN
1059-1524 .
PMC
4945142 .
PMID
27226487 .
^ Scarborough, Emily Anne; Davis, Trisha N; Asbury, Charles L (2019-05-02).
"Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules" . eLife . 8 . eLife Sciences Publications, Ltd.
doi :
10.7554/elife.44489 .
ISSN
2050-084X .
PMC
6516834 .
PMID
31045495 .
^ Kim, Jae ook; Zelter, Alex; Umbreit, Neil T; Bollozos, Athena; Riffle, Michael; Johnson, Richard; MacCoss, Michael J; Asbury, Charles L; Davis, Trisha N (2017-02-13).
"The Ndc80 complex bridges two Dam1 complex rings" . eLife . 6 . eLife Sciences Publications, Ltd.
doi :
10.7554/elife.21069 .
ISSN
2050-084X .
PMC
5354518 .
PMID
28191870 .
^ Zelter, Alex; Bonomi, Massimiliano; Kim, Jae ook; Umbreit, Neil T.; Hoopmann, Michael R.; Johnson, Richard; Riffle, Michael; Jaschob, Daniel; MacCoss, Michael J.; Moritz, Robert L.; Davis, Trisha N. (2015-11-12).
"The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling" . Nature Communications . 6 (1). Springer Science and Business Media LLC: 8673.
Bibcode :
2015NatCo...6.8673Z .
doi :
10.1038/ncomms9673 .
ISSN
2041-1723 .
PMC
4660060 .
PMID
26560693 .
^ Powers, Andrew F.; Franck, Andrew D.; Gestaut, Daniel R.; Cooper, Jeremy; Gracyzk, Beth; Wei, Ronnie R.; Wordeman, Linda; Davis, Trisha N.; Asbury, Charles L. (2009).
"The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion" . Cell . 136 (5). Elsevier BV: 865–875.
doi :
10.1016/j.cell.2008.12.045 .
ISSN
0092-8674 .
PMC
2749323 .
PMID
19269365 .
^
"UW president, biochemistry chair and mathematics professor named to American Academy of Arts and Sciences" . UW News . 2020-04-23. Retrieved 2020-05-12 .
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