| Transient bullous dermolysis of the newborn | |
|---|---|
| Specialty | Dermatology |
Transient bullous dermolysis of the newborn (TBDN) is a skin condition that presents in newborns. It is characterized by blister formation secondary to even mild trauma. [1]: 558
A subtype of dystrophic epidermolysis bullosa, [2] it is rare, usually inherited condition that presents with characteristic blisters at birth which resolve between six months and one year of age. [3]
Blisters may cover the entire body including the mouth, and as they heal, they may leave some mild scarring. In addition, nail changes may occur which can persist to adulthood. [3]
It is associated with COL7A1. [4]
The condition was described by Ken Hashimoto in 1985. [5] [6]
See also
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 78. doi: 10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. S2CID 221861310.
- ^ a b "Transient bullous dermolysis of the newborn | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 11 August 2018.
- ^ Hammami-Hauasli N, Raghunath M, Küster W, Bruckner-Tuderman L (December 1998). "Transient bullous dermolysis of the newborn associated with compound heterozygosity for recessive and dominant COL7A1 mutations". J. Invest. Dermatol. 111 (6): 1214–9. doi: 10.1046/j.1523-1747.1998.00394.x. PMID 9856844.
- ^ John Thorne Crissey; Lawrence C. Parish; Karl Holubar (2013). Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 179. ISBN 978-1-84214-100-7.
- ^ Murase, K; Kanoh, H; Ishii, N; Hashimoto, T; Nakano, H; Sawamura, D; Seishima, M (2011). "Bullous Dermolysis of the Newborn and Dystrophic Epidermolysis Bullosa Pruriginosa within the Same Family: Two Phenotypes Associated with a COL7A1 Mutation". Acta Dermato Venereologica. 91 (6): 730–731. doi: 10.2340/00015555-1154. ISSN 0001-5555. PMID 21629976.
External links