This condition is inherited in an autosomal recessive manner
Acropachy is a dermopathy associated with
Graves' disease.[1] It is characterized by soft-tissue swelling of the hands and
clubbing of the fingers.
Radiographic imaging of affected extremities typically demonstrates
periostitis, most commonly the
metacarpal bones. The exact cause is unknown, but it is thought to be caused by stimulating auto-antibodies that are implicated in the
pathophysiology of Graves'
thyrotoxicosis. There is no effective treatment for acropachy.
Since it is closely associated with Graves' disease, it is associated with other manifestations of Graves' disease, such as Graves'
ophthalmopathy[2] and
thyroid dermopathy.[3]
Hereditary acropachy (also known as "isolated congenital nail clubbing") may be associated with
HPGD.[4]
^Tariq M, Azeem Z, Ali G, Chishti MS, Ahmad W (January 2009). "Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)". J. Med. Genet. 46 (1): 14–20.
doi:
10.1136/jmg.2008.061234.
PMID18805827.