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Chemical compound
Core structure of thienotriazolodiazepines
A thienotriazolodiazepine
[1] is a heterocyclic compound containing a
diazepine ring fused to
thiophene and
triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:
Thienotriazolodiazepines interact with the
benzodiazepine receptor site, they typically have similar effects as 1,4-
benzodiazepines (such as
diazepam ) and triazolobenzodiazepines (such as
alprazolam ).
Thienotriazolodiazepines that are not
GABAA receptor positive allosteric modulators include:
References
^ Catabay, A.; Taniguchi, M.; Jinno, K.; Pesek, J. J.; Williamsen, E. (1 March 1998).
"Separation of 1,4-Benzodiazepines and Analogues Using Cholesteryl-10-Undecenoate Bonded Phase in Microcolumn Liquid Chromatography" . Journal of Chromatographic Science . 36 (3): 113.
doi :
10.1093/chromsci/36.3.111 .
^ Hirota, N; Yasuda, D; Hashidate, T; Yamamoto, T; Yamaguchi, S; Nagamune, T; Nagase, T; Shimizu, T; Nakamura, M (Feb 2010).
"Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor" . Journal of Biological Chemistry . 285 (8): 5931–40.
doi :
10.1074/jbc.M109.066282 .
PMC
2820818 .
PMID
20007715 .