In human clinical study, there have been mixed observations in preliminary studies. One
Phase I study showed no significant changes in the blood lipids or free fatty acids[4] and another showed that TTA attenuates
dyslipidemia in patients with
type 2 diabetes mellitus.[1]
References
^
abLøvås, K; Røst, TH; Skorve, J; Ulvik, RJ; Gudbrandsen, OA; Bohov, P; Wensaas, AJ; Rustan, AC; et al. (2009). "Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation". Diabetes, Obesity & Metabolism. 11 (4): 304–14.
doi:
10.1111/j.1463-1326.2008.00958.x.
PMID19267708.
S2CID22883377.
^Bjørndal, B; Grimstad, T; Cacabelos, D; Nylund, K; Aasprong, OG; Omdal, R; Portero-Otin, M; Pamplona, R; Lied, GA; Hausken, Trygve; Berge, Rolf K. (2012). "Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats". Digestive Diseases and Sciences. 58 (1): 97–106.
doi:
10.1007/s10620-012-2321-2.
hdl:1956/6530.
PMID22855292.
S2CID1539648.