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Vitamin E was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (December 23, 2022, reviewed version). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated. |
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I had nominated this for GA review in March 2018, then withdrew the nomination in June 2018, as no reviewer had taken up the task. I intend to renominate it after Thiamine goes through the GA process. If that succeeds, it will be the 11th vitamin I've raised to GA, leaving only E and D. David notMD ( talk) 17:19, 3 August 2022 (UTC)
@ David notMD I have come across this source [1] I think it is high-quality and would belong on the article. I have not got full access to the source but there is also a press release about its findings [2]. The review concluded "The USPSTF also concludes with moderate certainty that there is no net benefit of supplementation with vitamin E for the prevention of cardiovascular disease or cancer." Do you think we should mention this in the "Cancer health claims" section? Psychologist Guy ( talk) 13:15, 5 October 2022 (UTC)
Checking for newer refs for the Research section David notMD ( talk) 14:22, 5 October 2022 (UTC)
Nominated. Now (waiting for a reviewer) is a good time to improve the article. David notMD ( talk) 00:59, 30 November 2022 (UTC)
The following discussion is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
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Reviewer: Etriusus ( talk · contribs) 04:04, 8 December 2022 (UTC)
I'll review this, always glad to see a Vital Article come through here. Immediately, I am worried about the handful of citation needed tags and the glaring number of sentences that are missing sources. I will keep the review open for now (until 12/15), since I am familiar with the general quality of your work, but I won't go much further until these issues are resolved. Once this is resolved, we can discuss a time frame for the rest of the page. I understand these topic can take time, vital articles tend to be a long haul. Thankfully, my degree is related close enough to this topic (Human Biology) for me to give a relatively technical review of the article.
Etrius (
Us) 04:04, 8 December 2022 (UTC)
Please use a Done, strikethrough or some other means of indicating an issue is resolved..
Technically, there is nothing inherently wrong with this copyright. That being said, a structural formula copyright (see File:Alpha-Tocopherol Structural Formulae V.1.svg) is more accurate. No other issues noted with the copyrights.
Earwig only flags 3-4 word proper nouns and phrases that really can't be reworded.
The missing citation issue has been raised above.
Intro
Vitamin E deficiency, which is rare and usually...move to the end of the paragraph
Both natural and synthetic tocopherols...Move to end of paragraph
Chemistry
The nutritional content...move to later in the paragraph, it doesn't make sense to introduce a RRR configuration before explaining methyl groups, adding to the end would work.
R" sitesYou and I know what this means but specify this is a functional group. I can potentially read like its a chiral center
Palm oil is a good source of alpha and gamma tocotrienolsout of place sentence
two corresponding centersThis should be reworded
which would have a 2S rather than 2R configuration at the molecules' single chiral centerredundant, also a bit confusing since it hasn't been established prior that dextrorotatory = R.
unlike synthetic dl-alpha-tocopherolkeep the terms consistent. Also, is this needed? perhaps saying an S config is theoretically possible but not commercially made gets the point across just fine.
Function
Vitamin E affects gene expressionNeeds to be expanded significantly. A cursory search has turned up a number of sources
Biosysthesis
chemical family of compounds made up of four tocopherols and four tocotrienolsreword
and plants that through mutations have lost the ability to synthesize α-tocopherol demonstrate normal growth.reword sentence, order of ideas is confusion
Deficiency
Dietary recommendations
The Japan National Institute of Health..sentence is clunky
Overall, this section is very well written. I'd love to see more countries represented.
Sources
Worldwide, consumption is below recommendations according to a summary of more than one hundred studies...repeat sentence, cut the preceding sentence or reword.
common form found in the North American dietany other diets/continents?
Metabolism
and all of the vitamin E vitamers are metabolized and then excreted via urine.unclear on what this means. I assume this means un-excreted bile.
so this appears to be a means of disposing of excess vitamin EI would hope urine is an excretory process. Rather redundant info
A rare genetic defect of the TTPA gene results in people exhibiting a progressive neurodegenerative disorder known as ataxia with vitamin E deficiency (AVED) despite consuming normal amounts of vitamin E. Large amounts of alpha-tocopherol as a dietary supplement are needed to compensate for the lack of α-TTPrepetitive, cut
As an example of a result of the preferential treatment, the US diet delivers approximately 70 mg/d of γ-tocopherol and plasma concentrations are on the order of 2–5 µmol/L; meanwhile, dietary α-tocopherol is about 7 mg/d but plasma concentrations are in the range of 11–37 µmol/LInfo is out of place
Testing for levels
Research Rename section to 'health effects' or something in that same vein
For the conditions described below...What is the purpose of this paragraph. It reads more like a disclaimer than a wiki article.
The European Food Safety Authority (EFSA) reviews proposed health claims for the European Union countries. As of September 2022,, EFSA has not evaluated any vitamin E and cancer prevention claims.missing citation
There are a number of instances where I'd love to see more coverage on other countries, or at least mention that other countries do not have dietary recommendations. On a broader scale, I am concerned that there is a no 'function' section. The Anti-oxidant function is buried in the chemistry section and the specific functions are spread amongst the entire article. This make it somewhat difficult to get a read on what Vitamin E actual does. This review was a beast but here are the first set of edits. I'll put this on hold but there is going to be some serious legwork ahead.
Etrius (
Us) 05:02, 15 December 2022 (UTC)
The following statement in this article:
There is use of vitamin E in skincare and wound-treatment products, but no clinical evidence that it is effective.
Uses reference 10 as support.
Reference 10 merely examined the question of the whether or not the topical use of Vitamin E during wound healing improves the cosmetic appearance of scarring after healing. There is no mention of any other potential benefits such as healing rate, inflammation reduction, or reduced infection rates.
There may still be no clinical evidence of any benefit from topical application of vitamin E. But, this reference is not sufficient support to come to that conclusion. Seanmcd27 ( talk) 00:36, 21 February 2023 (UTC)
The section Sources lists foods and their mg of vitamin E/100g of the food. But it lists "Canola/rapeseed oil" as 44 and "Canola oil" as 17.5. Clicking on the hyperlinks – canola, rapeseed, and canola oil – takes one to these pages: Rapeseed oil, Rapeseed, and Rapeseed oil again. The Rapeseed oil page quotes the 17.5 figure – but not as the α-tocopherol content, simply as vitamin E content – and cites fdc.nal.usda.gov. The Rapeseed one doesn’t list contents.
The section says “The last major revision was Release 28, September 2015.”. The USDA website says that release 28 is not going to be updated, and that this data is to be found via the Food and Nutrient Database for Dietary Studies (FNDDS). (So instead of typing in the food and seeing the values for it, one has to download a 6Mb spreadsheet and search in it!)
Going to the cited site, fdc.nal.usda.gov/fdc-app.html#/food-details/748278/nutrients, one can read that canola oil’s vitamin E content is made up of four of the eight vitamin E compounds, and it gives these averages, again in mg/100g: α-tocopherol, 17.3 ... γ-tocopherol, 41.3 ... δ-tocopherol, 1.48 ... and β-tocotrienol, 8.07.
And going to the FNDDS site, it confirms the 17.3 figure, but not the other three, which it doesn’t mention.
So why is α-tocopherol used as a proxy for vitamin E content? Why the 44 figure for "Canola/rapeseed oil"? And why this 17.5 figure, and not 17.3? It appears that there could be a mistake somewhere along the line, or at least, a bit of confused explanation. If there isn’t, a sentence of explanation would help, I.M.O. Nick Barnett ( talk) 14:57, 21 February 2024 (UTC)
A key concern with vitamin E is its relationship with readily oxidized linoleic acid. This fatty acid is unstable but associated with vitamin E. Hence, linoleic in the diet confounds research based on 'independent' changes in vitamin E doses or those that achieve vitamin E through the diet via ingestion of vegetables. Further, oxidation of linoleic acid is likely to manifest in chronic diseases that may take a decade or so to arise. Few studies have been designed with these mechanisms in mind. Another confounder is the intake of vitamin C, which provides 'recharging' of vitamin E that has neutralized an ROS. Finally, with its brain and muscles, the human body represents a substantively more oxidizing condition than that found in plants, and it is reasonable to entertain the idea that the humans need more vitamin E relative to plants. Drmartz ( talk) 20:16, 24 April 2024 (UTC)