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I am interested in making some rather substantial changes to this page, but thought it might be best to float some ideas here first.
An example: the second (short) paragraph says:
"New research indicates that small RNAs 21-25 nucleotides in length called miRNAs can control expression of these genes by downregulating them."
This sentence is true, and there is a lot of interest to say about miRNAs and their involvement in cancer, but the above makes a generic statement about all genes that says nothing specific about oncogenes. On that basis, I would delete this paragraph.
Comments?
User:OncoAnalyst forgot to sign the above.
Delete or rewrite. I would start by rewriting the above as " microRNAs can control expression of these genes by downregulating them." and add relevant sources. Also please rewrite the section on the microRNA page about cancer. Una Smith 04:35, 14 June 2007 (UTC)
While I agree the connections between miRNAs and oncogenes are beginning to become intriguing, I really don't feel it belongs at the beginning of the article. I'm a big fan of the idea that these entries should be written in the "funnel" style, where we start with the most broad statements and then move on to specifics. In that light, miRNAs belong as a sub-heading later on in the article--placing them at the beginning is just confusing. It also doesn't necessarily contribute anything to the basic understanding of what an "oncogene" is.
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:30, 10 November 2007 (UTC)
Someone has added extra material:
"so they pretty much suck" "loss of bladder control" "a condition called proto-syntheticcanceritis"
I don't want to remove it without discussion, hence this new section. -klode —Preceding unsigned comment added by 204.92.192.254 ( talk) 05:31, 27 January 2008 (UTC)
"Since the 1970s, dozens of oncogenes have been identified in cancer." and "Since the 1980s, dozens of oncogenes have been identified in human cancer." Cheers, Jack ( talk) 14:29, 9 May 2008 (UTC)
I searched this article trying to understand the difference between an oncogene and a protooncogene. Their definition seem the same to me in this article, just with slightly different words. —Preceding unsigned comment added by 201.66.199.182 ( talk) 23:44, 31 January 2009 (UTC)
I also came here to understand the distinction between proto-oncogene and oncogene, which is not at all clear in the article. I would like to add that the problem is further compounded by having an "activated-oncogene". If you start with the proto-oncogene as the non-mutated version of the gene then the mutated form (the oncogene) would seem to be the (activated) oncogene! Hope somebody can clarify the associated between these three terms in the article. Thanks. 165.225.81.77 ( talk) 16:09, 23 April 2019 (UTC)
In the proto oncogene section it says "Another example of an oncogene is the Bcr-Abl gene found on the Philadelphia Chromosome" the bolded section seams wrong but I don't know what to replace it with. — Preceding unsigned comment added by 32.171.62.41 ( talk) 12:20, 29 May 2012 (UTC)
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