Combination of | |
---|---|
Fibrinogen | Glycoprotein |
Thrombin | Coagulation factor |
Clinical data | |
Trade names | Tachosil |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Routes of administration | Epilesional |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
KEGG |
Tachosil is an equine collagen sponge coated with the human plasma-derived coagulation factors fibrinogen and thrombin. [2] [5] It is used during surgery to stop local bleeding on internal organs ( hemostasis). [2] Tachosil reacts upon contact with blood, other body fluids or saline to form a clot that glues it to the tissue surface. [4]
Tachosil may cause an allergic reaction, thrombosis (blood clots), a blockage in the intestine when used during abdominal surgeries, the formation of scar tissue and foreign body granuloma (a type of inflammatory reaction). [4]
Tachosil is indicated in for supportive treatment in surgery for improvement of haemostasis, to promote tissue sealing and for suture support in vascular surgery where standard techniques are insufficient. [4] According to studies comparing Tachosil to argon beamer or stitching in patients undergoing liver surgery, Tachosil was associated with significantly lower time until the bleeding stopped. [1] Tachosil is indicated in adults for supportive sealing of the dura mater to prevent postoperative cerebrospinal leakage following neurological surgery. [4]