Trypsin domain containing 1 is a
protein that in humans is encoded by the TYSND1
gene.
[5]
Function
This gene encodes a
protease that removes the N-terminal peroxisomal targeting signal (
PTS2) from proteins produced in the
cytosol, thereby facilitating their import into the
peroxisome.
The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple
transcript variants for this gene.