TNIK References

TNIK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X7F, 5CWZ, 5AX9
Identifiers
Aliases	TNIK, TRAF2 and NCK interacting kinase, MRT54
External IDs	OMIM: 610005 MGI: 1916264 HomoloGene: 77943 GeneCards: TNIK
Gene location ( Human)
Chr.	Chromosome 3 (human)
End	171,460,408 bp
Gene location ( Mouse)
Chr.	Chromosome 3 (mouse)
End	28,730,007 bp
RNA expression pattern
	Top expressed in
	oocyte; ; caudate nucleus; ; jejunal mucosa; ; secondary oocyte; ; nucleus accumbens; ; putamen; ; corpus callosum; ; internal globus pallidus; ; duodenum; ; Brodmann area 46;
	Top expressed in
	superior cervical ganglion; ; trigeminal ganglion; ; ventromedial nucleus; ; temporal lobe; ; mammillary body; ; lateral hypothalamus; ; superior frontal gyrus; ; amygdala; ; olfactory bulb; ; facial motor nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm; recycling endosome; endosome; nucleoplasm; apical plasma membrane; extracellular exosome; cytoskeleton; nucleus; cytosol; presynapse; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	actin cytoskeleton reorganization; microvillus assembly; positive regulation of protein phosphorylation; intracellular signal transduction; phosphorylation; Wnt signaling pathway; nervous system development; regulation of dendrite morphogenesis; protein phosphorylation; cytoskeleton organization; protein autophosphorylation; protein localization to plasma membrane; regulation of mitotic cell cycle; regulation of apoptotic process; MAPK cascade; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; neuron projection morphogenesis;
	Sources: Amigo / QuickGO
Orthologs
	23043
	665113
	ENSG00000154310
	ENSMUSG00000027692
	Q9UKE5
	P83510
NM_001161560; NM_001161561; NM_001161562; NM_001161563; NM_001161564;
	NM_001161565; NM_001161566; NM_015028
	NM_001163007; NM_001163008; NM_001163009; NM_026910
NP_001155032; NP_001155033; NP_001155034; NP_001155035; NP_001155036;
	NP_001155037; NP_001155038; NP_055843
	NP_001156479; NP_001156480; NP_001156481; NP_081186
	Wikidata
View/Edit Human	View/Edit Mouse

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.^[5]^[6]^[7]

Function

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.^[6]^[7]

Interactions

TNIK has been shown to interact with KIAA0090,^[8] although the significance is unclear. TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes.^[6]

TNIK plays an important role in pulmonary fibrosis. Inhibitors of TNIK are used in the treatment of pulmonary fibrosis. ^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027692 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31. PMID 9628581.
^ ^a ^b ^c Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem. 274 (43): 30729–37. doi: 10.1074/jbc.274.43.30729. PMID 10521462.
^ ^a ^b "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".
^ Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi: 10.1093/nar/gkl128. PMC 1538863. PMID 16845013. Archived from the original on 2010-04-09.
^ Garneau-Tsodikova, Sylvie; Thannickal, Victor J. (2008). "Protein kinase inhibitors in the treatment of pulmonary fibrosis". Current Medicinal Chemistry. 15 (25): 2632–2640. doi: 10.2174/092986708785908969. ISSN 0929-8673. PMID 18855683.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99. PMID 12168954.
Yonekura H, Migita H, Sakurai S, et al. (1999). "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes". Nucleic Acids Res. 27 (13): 2591–600. doi: 10.1093/nar/27.13.2591. PMC 148466. PMID 10373574.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi: 10.1021/ac035352d. PMID 15144186.
Taira K, Umikawa M, Takei K, et al. (2005). "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton". J. Biol. Chem. 279 (47): 49488–96. doi: 10.1074/jbc.M406370200. PMID 15342639.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200. hdl: 10033/19756. PMID 17192257.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027692 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9628581-5] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31. PMID 9628581.

[pmid10521462-6] Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y (Nov 1999). "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton". J Biol Chem. 274 (43): 30729–37. doi: 10.1074/jbc.274.43.30729. PMID 10521462.

[entrez-7] "Entrez Gene: TNIK TRAF2 and NCK interacting kinase".

[pmid16845013-8] Prieto C, De Las Rivas J (July 2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Res. 34 (Web Server issue): W298–302. doi: 10.1093/nar/gkl128. PMC 1538863. PMID 16845013. Archived from the original on 2010-04-09.

[9] Garneau-Tsodikova, Sylvie; Thannickal, Victor J. (2008). "Protein kinase inhibitors in the treatment of pulmonary fibrosis". Current Medicinal Chemistry. 15 (25): 2632–2640. doi: 10.2174/092986708785908969. ISSN 0929-8673. PMID 18855683.

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Function

Interactions

References

Further reading