From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
THO complex subunit 1 is a
protein that in humans is encoded by the THOC1
gene .
[5]
[6]
HPR1 is part of the
TREX (transcription/export) complex , which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]
[6]
Interactions
THOC1 has been shown to
interact with
Retinoblastoma protein .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000079134 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000024287 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature . 417 (6886): 304–8.
Bibcode :
2002Natur.417..304S .
doi :
10.1038/nature746 .
PMID
11979277 .
S2CID
1112194 .
^
a
b
"Entrez Gene: THOC1 THO complex 1" .
^ Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994).
"The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing" . J. Cell Biol . 127 (3): 609–22.
doi :
10.1083/jcb.127.3.609 .
ISSN
0021-9525 .
PMC
2120229 .
PMID
7525595 .
Further reading
Durfee T, Mancini MA, Jones D, et al. (1994).
"The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing" . J. Cell Biol . 127 (3): 609–22.
doi :
10.1083/jcb.127.3.609 .
PMC
2120229 .
PMID
7525595 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics . 83 (3): 493–501.
doi :
10.1016/j.ygeno.2003.08.017 .
PMID
14962675 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Gasparri F, Sola F, Locatelli G, Muzio M (2004). "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm". FEBS Lett . 574 (1–3): 13–9.
doi :
10.1016/j.febslet.2004.07.074 .
PMID
15358532 .
S2CID
43023236 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Li Y, Wang X, Zhang X, Goodrich DW (2005).
"Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors" . Mol. Cell. Biol . 25 (10): 4023–33.
doi :
10.1128/MCB.25.10.4023-4033.2005 .
PMC
1087710 .
PMID
15870275 .
Masuda S, Das R, Cheng H, et al. (2005).
"Recruitment of the human TREX complex to mRNA during splicing" . Genes Dev . 19 (13): 1512–7.
doi :
10.1101/gad.1302205 .
PMC
1172058 .
PMID
15998806 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Li Y, Lin AW, Zhang X, et al. (2007).
"Cancer cells and normal cells differ in their requirements for Thoc1" . Cancer Res . 67 (14): 6657–64.
doi :
10.1158/0008-5472.CAN-06-3234 .
PMC
2804983 .
PMID
17638875 .
Garner E, Martinon F, Tschopp J, et al. (2007).
"Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6" . Cancer Res . 67 (16): 7631–7.
doi :
10.1158/0008-5472.CAN-07-0334 .
PMID
17699767 .