From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ELOC
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1LM8 ,
1LQB ,
1VCB ,
2C9W ,
2IZV ,
2MA9 ,
3DCG ,
3ZKJ ,
3ZNG ,
3ZRC ,
3ZRF ,
3ZTC ,
3ZTD ,
3ZUN ,
4AJY ,
4AWJ ,
4B95 ,
4B9K ,
4BKS ,
4BKT ,
4N9F ,
4W9C ,
4W9D ,
4W9E ,
4W9F ,
4W9G ,
4W9H ,
4W9I ,
4W9J ,
4W9K ,
4W9L ,
4WQO ,
5BO4
Identifiers
Aliases
ELOC , SIII, eloC, TCEB1, transcription elongation factor B subunit 1, elongin CExternal IDs
OMIM :
600788
MGI :
1915173
HomoloGene :
38083
GeneCards :
ELOC
Wikidata
Elongin C is a
protein that in humans is encoded by the ELOC
gene .
[5]
[6]
Function
Elongin C is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by
RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The
von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
[7]
Interactions
TCEB1 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000154582 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000079658 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Garrett KP, Haque D, Conaway RC, Conaway JW (Feb 1995). "A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII". Gene . 150 (2): 413–4.
doi :
10.1016/0378-1119(94)90467-7 .
PMID
7821821 .
^ Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD (Oct 1995).
"Inhibition of transcription elongation by the VHL tumor suppressor protein" . Science . 269 (5229): 1402–6.
Bibcode :
1995Sci...269.1402D .
doi :
10.1126/science.7660122 .
PMID
7660122 .
S2CID
22334719 .
^
"Entrez Gene: TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)" .
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
^
a
b Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999).
"Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein" . J. Clin. Invest . 104 (11): 1583–91.
doi :
10.1172/JCI8161 .
PMC
481054 .
PMID
10587522 .
^ Krumm A, Groudine M (Sep 1995). "Tumor suppression and transcription elongation: the dire consequences of changing partners". Science . 269 (5229): 1400–1.
Bibcode :
1995Sci...269.1400K .
doi :
10.1126/science.7660121 .
PMID
7660121 .
S2CID
39758696 .
^
a
b Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002).
"Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein" . J. Biol. Chem . 277 (7): 4656–62.
doi :
10.1074/jbc.M108269200 .
PMID
11739384 .
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 : 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
^ Tsuchiya H, Iseda T, Hino O (Jul 1996). "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product". Cancer Res . 56 (13): 2881–5.
PMID
8674032 .
^ Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (Jun 2002).
"Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling" . Science . 296 (5574): 1886–9.
Bibcode :
2002Sci...296.1886M .
doi :
10.1126/science.1073440 .
PMID
12004076 .
S2CID
19641938 .
^ Hacker KE, Lee CM, Rathmell WK (2008). Zhang B (ed.).
"VHL type 2B mutations retain VBC complex form and function" . PLOS ONE . 3 (11): e3801.
Bibcode :
2008PLoSO...3.3801H .
doi :
10.1371/journal.pone.0003801 .
PMC
2583047 .
PMID
19030229 .
^ Kim BY, Kim H, Cho EJ, Youn HD (Feb 2008).
"Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation" . Exp. Mol. Med . 40 (1): 71–83.
doi :
10.3858/emm.2008.40.1.71 .
PMC
2679322 .
PMID
18305400 .
Further reading
Aso T, Lane WS, Conaway JW, Conaway RC (1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science . 269 (5229): 1439–43.
Bibcode :
1995Sci...269.1439A .
doi :
10.1126/science.7660129 .
PMID
7660129 .
S2CID
37649908 .
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". Science . 269 (5229): 1444–6.
Bibcode :
1995Sci...269.1444K .
doi :
10.1126/science.7660130 .
PMID
7660130 .
S2CID
25410108 .
Bradsher JN, Jackson KW, Conaway RC, Conaway JW (1994).
"RNA polymerase II transcription factor SIII. I. Identification, purification, and properties" . J. Biol. Chem . 268 (34): 25587–93.
doi :
10.1016/S0021-9258(19)74431-7 .
PMID
8244996 .
Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997).
"The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins" . Proc. Natl. Acad. Sci. U.S.A . 94 (6): 2156–61.
Bibcode :
1997PNAS...94.2156P .
doi :
10.1073/pnas.94.6.2156 .
PMC
20057 .
PMID
9122164 .
Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG (1998).
"Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2" . Mol. Cell. Biol . 18 (2): 732–41.
doi :
10.1128/mcb.18.2.732 .
PMC
108784 .
PMID
9447969 .
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M (1999).
"The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation" . Proc. Natl. Acad. Sci. U.S.A . 96 (5): 2071–6.
Bibcode :
1999PNAS...96.2071Z .
doi :
10.1073/pnas.96.5.2071 .
PMC
26738 .
PMID
10051596 .
Stebbins CE, Kaelin WG, Pavletich NP (1999). "Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function". Science . 284 (5413): 455–61.
Bibcode :
1999Sci...284..455S .
doi :
10.1126/science.284.5413.455 .
PMID
10205047 .
Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD (1999).
"Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9533–8.
Bibcode :
1999PNAS...96.9533P .
doi :
10.1073/pnas.96.17.9533 .
PMC
22243 .
PMID
10449727 .
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A (1999).
"Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex" . Proc. Natl. Acad. Sci. U.S.A . 96 (22): 12436–41.
Bibcode :
1999PNAS...9612436I .
doi :
10.1073/pnas.96.22.12436 .
PMC
22941 .
PMID
10535940 .
Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (2000).
"Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein" . J. Clin. Invest . 104 (11): 1583–91.
doi :
10.1172/JCI8161 .
PMC
481054 .
PMID
10587522 .
Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M (2000).
"Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis" . J. Biol. Chem . 275 (9): 6546–52.
doi :
10.1074/jbc.275.9.6546 .
PMID
10692460 .
Adryan B, Decker HJ, Papas TS, Hsu T (2000).
"Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila" . Oncogene . 19 (24): 2803–11.
doi :
10.1038/sj.onc.1203611 .
PMID
10851083 .
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000).
"Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (19): 10430–5.
Bibcode :
2000PNAS...9710430K .
doi :
10.1073/pnas.190332597 .
PMC
27041 .
PMID
10973499 .
Aso T, Yamazaki K, Aigaki T, Kitajima S (2000). "Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity". Biochem. Biophys. Res. Commun . 276 (1): 355–61.
doi :
10.1006/bbrc.2000.3451 .
PMID
11006129 .
Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (2001).
"Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase" . J. Biol. Chem . 276 (32): 29748–53.
doi :
10.1074/jbc.M103093200 .
PMID
11384984 .
Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002).
"Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein" . J. Biol. Chem . 277 (7): 4656–62.
doi :
10.1074/jbc.M108269200 .
PMID
11739384 .
Yamazaki K, Guo L, Sugahara K, Zhang C, Enzan H, Nakabeppu Y, Kitajima S, Aso T (2002).
"Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3" . J. Biol. Chem . 277 (29): 26444–51.
doi :
10.1074/jbc.M202859200 .
PMID
11994304 .
Porkka K, Saramäki O, Tanner M, Visakorpi T (2002).
"Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays" . Lab. Invest . 82 (5): 629–37.
doi :
10.1038/labinvest.3780457 .
PMID
12004003 .
PDB gallery
1lm8 : Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex
1lqb : Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
1vcb : THE VHL-ELONGINC-ELONGINB STRUCTURE
2c9w : CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
2fnj : Crystal structure of a B30.2/SPRY domain-containing protein GUSTAVUS in complex with Elongin B and Elongin C
2izv : CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION