t(11;14) is a
chromosomal translocation which essentially always involves the
immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14 , as well as
cyclin D1 which is located in the q13 of chromosome 11 .[2] Specifically, the translocation is at t(11;14)(q13;q32).[3][4]
In multiple myeloma, t(11;14) is a neutral prognostic factor in general, but it may confer a worse prognosis for overall survival in African American people with multiple myeloma.[5]
References
^Semple CA, Devon RS, Le Hellard S, Porteous DJ (April 2001). "Identification of genes from a schizophrenia-linked translocation breakpoint region". Genomics. 73 (1): 123–6.
doi:
10.1006/geno.2001.6516.
PMID11352574.
^Barouk-Simonet E, Andrieux J, Copin MC, et al. (2002). "TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma". Ann. Genet. 45 (3): 165–8.
doi:
10.1016/S0003-3995(02)01122-X.
PMID12381451.