From Wikipedia, the free encyclopedia
Protein found in humans
SDCBP
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1N99 ,
1NTE ,
1OBX ,
1OBY ,
1OBZ ,
1R6J ,
1V1T ,
1W9E ,
1W9O ,
1W9Q ,
1YBO ,
4Z33
Identifiers
Aliases
SDCBP , MDA-9, ST1, SYCL, TACIP18, MDA9, syndecan binding proteinExternal IDs
OMIM :
602217
MGI :
1337026
HomoloGene :
4110
GeneCards :
SDCBP
Wikidata
Syntenin-1 is a
protein that in humans is encoded by the SDCBP
gene .
[5]
Function
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
[6]
Interactions
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000137575 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028249 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Dürr J, David G (January 1998).
"Syntenin, a PDZ protein that binds syndecan cytoplasmic domains" . Proc Natl Acad Sci USA . 94 (25): 13683–8.
Bibcode :
1997PNAS...9413683G .
doi :
10.1073/pnas.94.25.13683 .
PMC
28366 .
PMID
9391086 .
^
"Entrez Gene: SDCBP syndecan binding protein (syntenin)" .
^ Lin D, Gish GD, Songyang Z, Pawson T (February 1999).
"The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif" . J. Biol. Chem . 274 (6): 3726–33.
doi :
10.1074/jbc.274.6.3726 .
PMID
9920925 .
^
a
b Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003).
"Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP" . Neuron . 37 (4): 625–38.
doi :
10.1016/s0896-6273(02)01191-1 .
PMC
3314502 .
PMID
12597860 .
^ Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002).
"The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" . J. Biol. Chem . 277 (18): 15221–4.
doi :
10.1074/jbc.C200112200 .
hdl :
2262/89271 .
PMID
11891216 .
^
a
b Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science . 293 (5532): 1136–8.
doi :
10.1126/science.1059157 .
PMID
11498591 .
S2CID
28003281 .
^ Jannatipour M, Dion P, Khan S, Jindal H, Fan X, Laganière J, Chishti AH, Rouleau GA (August 2001).
"Schwannomin isoform-1 interacts with syntenin via PDZ domains" . J. Biol. Chem . 276 (35): 33093–100.
doi :
10.1074/jbc.M105792200 .
PMID
11432873 .
^
a
b Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004).
"Role of Unc51.1 and its binding partners in CNS axon outgrowth" . Genes Dev . 18 (5): 541–58.
doi :
10.1101/gad.1151204 .
PMC
374236 .
PMID
15014045 .
^ Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D (April 2008). "Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling". Cell. Signal . 20 (4): 666–74.
doi :
10.1016/j.cellsig.2007.12.002 .
PMID
18234474 .
S2CID
28812149 .
^
"Results - mentha: the interactome browser" . mentha.uniroma2.it . Retrieved 2017-05-04 .
Further reading
Bass MD, Humphries MJ (2002).
"Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling" . Biochem. J . 368 (Pt 1): 1–15.
doi :
10.1042/BJ20021228 .
PMC
1222989 .
PMID
12241528 .
Harrod TR, Justement LB (2003). "Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology". Immunol. Res . 26 (1–3): 153–66.
doi :
10.1385/IR:26:1-3:153 .
PMID
12403354 .
S2CID
26502472 .
Sarkar D, Boukerche H, Su ZZ, Fisher PB (2005). "mda-9/syntenin: recent insights into a novel cell signaling and metastasis-associated gene". Pharmacol. Ther . 104 (2): 101–15.
doi :
10.1016/j.pharmthera.2004.08.004 .
PMID
15518882 .
"Letter: The condition of psychiatry". N. Engl. J. Med . 292 (18): 982. 1975.
doi :
10.1056/NEJM197505012921826 .
PMID
1117941 .
Lin JJ, Jiang H, Fisher PB (1998). "Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene". Gene . 207 (2): 105–10.
doi :
10.1016/S0378-1119(97)00562-3 .
PMID
9511750 .
Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999).
"PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands" . Neuron . 21 (6): 1453–63.
doi :
10.1016/S0896-6273(00)80663-7 .
PMID
9883737 .
S2CID
15441813 .
Lin D, Gish GD, Songyang Z, Pawson T (1999).
"The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif" . J. Biol. Chem . 274 (6): 3726–33.
doi :
10.1074/jbc.274.6.3726 .
PMID
9920925 .
Fernández-Larrea J, Merlos-Suárez A, Ureña JM, Baselga J, Arribas J (1999).
"A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface" . Mol. Cell . 3 (4): 423–33.
doi :
10.1016/S1097-2765(00)80470-0 .
PMID
10230395 .
Fialka I, Steinlein P, Ahorn H, Böck G, Burbelo PD, Haberfellner M, Lottspeich F, Paiha K, Pasquali C, Huber LA (1999).
"Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells" . J. Biol. Chem . 274 (37): 26233–9.
doi :
10.1074/jbc.274.37.26233 .
PMID
10473577 .
Grootjans JJ, Reekmans G, Ceulemans H, David G (2000).
"Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin" . J. Biol. Chem . 275 (26): 19933–41.
doi :
10.1074/jbc.M002459200 .
PMID
10770943 .
Koroll M, Rathjen FG, Volkmer H (2001).
"The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity" . J. Biol. Chem . 276 (14): 10646–54.
doi :
10.1074/jbc.M010647200 .
PMID
11152476 .
Zimmermann P, Tomatis D, Rosas M, Grootjans J, Leenaerts I, Degeest G, Reekmans G, Coomans C, David G (2001).
"Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments" . Mol. Biol. Cell . 12 (2): 339–50.
doi :
10.1091/mbc.12.2.339 .
PMC
30947 .
PMID
11179419 .
Jannatipour M, Dion P, Khan S, Jindal H, Fan X, Laganière J, Chishti AH, Rouleau GA (2001).
"Schwannomin isoform-1 interacts with syntenin via PDZ domains" . J. Biol. Chem . 276 (35): 33093–100.
doi :
10.1074/jbc.M105792200 .
PMID
11432873 .
Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science . 293 (5532): 1136–8.
doi :
10.1126/science.1059157 .
PMID
11498591 .
S2CID
28003281 .
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002).
"The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" (PDF) . J. Biol. Chem . 277 (18): 15221–4.
doi :
10.1074/jbc.C200112200 .
PMID
11891216 .
S2CID
13732968 .
Koo TH, Lee JJ, Kim EM, Kim KW, Kim HD, Lee JH (2002).
"Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines" . Oncogene . 21 (26): 4080–8.
doi :
10.1038/sj.onc.1205514 .
PMID
12037664 .
Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, Südhof TC (2002). "SynCAM, a synaptic adhesion molecule that drives synapse assembly". Science . 297 (5586): 1525–31.
Bibcode :
2002Sci...297.1525B .
doi :
10.1126/science.1072356 .
PMID
12202822 .
S2CID
14529914 .
PDB gallery
1n99 : CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN
1nte : CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN
1obx : CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE.
1oby : CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.
1obz : CRYSTAL STRUCTURE OF THE COMPLEX OF THE PDZ TANDEM OF SYNTENIN WITH AN INTERLEUKIN 5 RECEPTOR ALPHA PEPTIDE.
1r6j : Ultrahigh resolution Crystal Structure of syntenin PDZ2
1v1t : CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYKV PEPTIDE
1w9e : CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEFYF PEPTIDE
1w9o : CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEYYV PEPTIDE
1w9q : CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN IN COMPLEX WITH TNEFAF PEPTIDE
1ybo : Crystal structure of the PDZ tandem of human syntenin with syndecan peptide