Suosan is a
sodiumsalt of p-Nitrophenylcarbamidopropionic acid and is 700 times sweeter than
sucrose (table sugar)[2] with a bitter aftertaste.[3] It was never commercialized due to its low solubility in water, particularly under acidic pH (which limited its use, particularly in
soft drinks)[4][5] and concerns that it might form the toxic compound
4-nitroaniline.[5]
^Petersen S; Muller E (1948). "Über eine neue Gruppe von Süsstoffen (On a new group of sweet substances)". Chemische Berichte. 81: 31–38.
doi:
10.1002/cber.19480810105.
^Santhosh, C.; Mishra, P. C. (1994). "Electrostatic potential and electric field mapping of some sweeteners of the suosan series: A search for the structure-activity relationship". International Journal of Quantum Chemistry. 51 (5): 335.
doi:
10.1002/qua.560510510.
^AD Kinghorn & CM Compadre (2001). "Less common high-potency sweeteners". In Marcel Dekker (ed.). Alternative Sweeteners (Third ed.). New York. pp. 208–234.
ISBN0-8247-0437-1.{{
cite book}}: CS1 maint: location missing publisher (
link)
^Muller, George W; Culberson, J. Chris; Roy, Glenn; Ziegler, Jeanette; Walters, D. Eric; Kellogg, Michael S.; Schiffman, Susan S.; Warwick, Zoe S (May 1992). "Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1". J. Med. Chem. 35 (10): 1747–1751.
doi:
10.1021/jm00088a008.
PMID1588556.