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Stuart C. Sealfon is an American neurologist who studies the mechanisms of both the therapeutic and adverse effects of drugs. He was an early adopter of the use of massively parallel qPCR and fluorescent in situ hybridization to characterize cell response state ^[1] and his research accomplishments have included the identification of the primary structure of the gonadotropin-releasing hormone receptor, finding new signaling pathways activated by drugs for Parkinson's disease, elucidating the mechanism of action of hallucinogens and finding a new brain receptor complex implicated in schizophrenia as a novel target for antipsychotics. ^{[2] [3] [4]}

Sealfon is the Glickenhaus Professor and Chairman of the Department of Neurology at The Mount Sinai School of Medicine in New York City. Sealfon also serves as director of Mount Sinai's Center for Translational Systems Biology. Additionally, he is both Professor of Neurobiology and Professor of Pharmacology and Systems Therapeutics. ^[5]

Sealfon is the author of multiple book chapters and is the editor of Receptor Molecular Biology, Volume 25 ( ISBN  0121852954). He has contributed to more than 100 original research articles and holds two patents.

Biography

Sealfon was born in 1956 in New York City. He was raised in Rockaway. He graduated magna cum laude Phi Beta Kappa from Princeton University in 1978 and received the thesis award in comparative literature. He received his M.D. in 1982 from Columbia University College of Physicians and Surgeons, where he was selected to the Alpha Omega Alpha Honor Medical Society. He completed an internship in medicine in 1983 and a residency in neurology in 1986 at Massachusetts General Hospital. After completing a fellowship in neuroscience at the Mount Sinai Medical Center, he was named assistant professor at the Mount Sinai School of Medicine in 1988.^{[ citation needed]}

Sealfon has served on the editorial boards of Endocrinology, ^[6] Endocrine Journal, Molecular Endocrinology and the Mount Sinai Journal of Medicine and served as reviewing editor of Biochemical Journal. Additionally, he served on the advisory board of the Alanex Corporation. ^[1]

Sealfon's work is supported by the National Institute on Drug Abuse, the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Allergy and Infectious Diseases. He directs the multi-institutional Program for Research on Immune Modeling and Experimentation (PRIME), an NIH-funded Modeling Immunity for the Biodefense Center. Through the Sealfon Laboratory and The Mount Sinai Medical Center, he oversees research on human hallucinogenic drugs of abuse, immune cell signaling, and gonadotrope signaling. ^{[7] [8] [9]}

Grants

A partial list of current grant support includes the following:

• GnRH Receptor Signaling Specificity, NIH, RO1 DK46943-14 ^[10]
• Mechanisms of Hallucinogens, NIH, PO1 DA12923-07
• Modeling Immunity for Biodefense, NO1 AI 50021 ^[11]

Patents

• 1998, U.S. #5,750,366, Cloning and Expression of Gonadotropin Releasing Hormone Receptor ^[12]
• 1999, U.S. #5,985,583, Applications of GnRH Receptor ^[13]

Publications

Partial list:

• Yuen T., Ruf F., Chu T., Sealfon S.C. (2009). "Microtranscriptome regulation by gonadotropin-releasing hormone". Mol Cell Endocrinol. 302 (1): 12–7. doi: 10.1016/j.mce.2008.12.013. PMC  2683625. PMID  19356622.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Sugar I.P., Sealfon S.C. (2009). "Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem B. 113 (31): 10946–56. doi: 10.1021/jp903518x. PMID  19601596.
• Gonzalez-Maeso J., Sealfon S.C. (2009). "Psychedelics and schizophrenia". Trends Neurosci. 32 (4): 225–32. doi: 10.1016/j.tins.2008.12.005. PMID  19269047. S2CID  35774080.
• Gonzalez-Maeso J., Ang R.L., Yuen T., Chan P., Weisstaub N.V., Lopez-Gimenez J.F., Zhou M., Okawa Y., Callado L.F., Milligan G., Gingrich J.A., Filizola M., Meana J.J., Sealfon S.C. (2008). "Identification of a serotonin/glutamate receptor complex implicated in psychosis". Nature. 452 (7183): 93–7. Bibcode: 2008Natur.452...93G. doi: 10.1038/nature06612. PMC  2743172. PMID  18297054.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Borderia A.V., Hartmann B.M., Fernandez-Sesma A., Moran T.M., Sealfon S.C. (2008). "Antiviral-activated dendritic cells: a paracrine-induced response state". J Immunol. 181 (10): 6872–81. doi: 10.4049/jimmunol.181.10.6872. PMC  4843808. PMID  18981106.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Ruf F., Hayot F., Park M.J., Ge Y., Lin G., Roysam B., Sealfon S.C. (2007). "Noise propagation and scaling in regulation of gonadotrope biosynthesis". Biophys J. 93 (12): 4474–80. Bibcode: 2007BpJ....93.4474R. doi: 10.1529/biophysj.107.115170. PMC  2098712. PMID  17720728.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Hu J., Sealfon S.C., Hayot F., Jayaprakash C., Kumar M., Pendleton A.C., Ganee A., Fernandez-Sesma A., Moran T.M., Wetmur J.G. (2007). "Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells". Nucleic Acids Res. 35 (15): 5232–41. doi: 10.1093/nar/gkm557. PMC  1976463. PMID  17675303.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Grisotto MG, Garin A, Martin AP, Jensen KK, Chan P, Sealfon SC, Lira SA (2006). "The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells". J Clin Invest. 116 (5): 1264–1273. doi: 10.1172/jci26666. PMC  1430356. PMID  16604194.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Moriarty TM, Sealfon SC, Carty CJ, Roberts JL, Iyengar R, Landau EM (1989). "Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin sensitive and insensitive pathways". J. Biol. Chem. 264 (23): 13524–13530. doi: 10.1016/S0021-9258(18)80028-X. PMID  2474532.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Gonzalez-Maeso J., Weisstaub N.V., Zhou M., Chan P., Ivic L., Ang R., Lira A., Bradley-Moore M., Ge Y., Zhou Q., Sealfon S.C., Gingrich J.A. (2007). "Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior". Neuron. 53 (3): 439–52. doi: 10.1016/j.neuron.2007.01.008. PMID  17270739.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Ruf F., Park M.J., Hayot F., Lin G., Roysam B., Ge Y., Sealfon S.C. (2006). "Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone". J Biol Chem. 281 (41): 30967–78. doi: 10.1074/jbc.M606486200. PMID  16916798.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Nair V.D., McNaught K.S., Gonzalez-Maeso J., Sealfon S.C., Olanow C.W. (2006). "p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition". J Biol Chem. 281 (51): 39550–60. doi: 10.1074/jbc.M603950200. PMID  17060322.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Chan P., Yuen T., Ruf F., Gonzalez-Maeso J., Sealfon S.C. (2005). "Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization". Nucleic Acids Res. 33 (18): e161. doi: 10.1093/nar/gni162. PMC  1258180. PMID  16224100.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Wurmbach E., Yuen T., Ebersole B.J., Sealfon S.C. (2001). "Gonadotropin-releasing hormone receptor-coupled gene network organization". J Biol Chem. 276 (50): 47195–201. doi: 10.1074/jbc.M108716200. PMID  11581274.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Mitchell R., McCulloch D., Lutz E., Johnson M., MacKenzie C., Fennell M., Fink G., Zhou W., Sealfon S.C. (1998). "Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.". Nature. 392 (6674): 411–4. Bibcode: 1998Natur.392..411M. doi: 10.1038/32937. PMID  9537328. S2CID  4430333.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)
• Tsutsumi M., Zhou W., Millar R.P., Mellon P.L., Roberts J.L., Flanagan C.A., Dong K., Gillo B., Sealfon S.C. (1992). "Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor". Mol Endocrinol. 6 (7): 1163–9. doi: 10.1210/mend.6.7.1324422. PMID  1324422.{{ cite journal}}: CS1 maint: multiple names: authors list ( link)

References

External links

• The Mount Sinai Hospital homepage
• The Mount Sinai School of Medicine homepage