From Wikipedia, the free encyclopedia
Stephen Friend at NightScience 2013 in Paris
Stephen H. Friend is co-founder and director of
Sage Bionetworks .
[1]
[2]
[3]
Formerly Senior Vice-president at
Merck & Co. Friend co-founded Rosetta Inpharmatics with
Leland H. Hartwell and
Leroy Hood in 1996.
[4] Much of his research has focused on
cancer .
[5]
Friend has also held faculty positions at
Harvard Medical School and at
Massachusetts General Hospital . He received his
Bachelor of Arts in philosophy, his
Ph.D. in biochemistry and his M.D. from
Indiana University .
[2]
Recognition
Friend is named an Ashoka Fellow by
Ashoka: Innovators for the Public in 2011.
[6]
Selected bibliography
Bartz, S. R.; Zhang, Z; Burchard, J; Imakura, M; Martin, M; Palmieri, A; Needham, R; Guo, J; Gordon, M; Chung, N; Warrener, P; Jackson, A. L.; Carleton, M; Oatley, M; Locco, L; Santini, F; Smith, T; Kunapuli, P; Ferrer, M; Strulovici, B; Friend, S. H.; Linsley, P. S. (2006).
"Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions" . Molecular and Cellular Biology . 26 (24): 9377–86.
doi :
10.1128/MCB.01229-06 .
PMC
1698535 .
PMID
17000754 .
Radich, J. P.; Dai, H; Mao, M; Oehler, V; Schelter, J; Druker, B; Sawyers, C; Shah, N; Stock, W; Willman, C. L.; Friend, S; Linsley, P. S. (2006).
"Gene expression changes associated with progression and response in chronic myeloid leukemia" . Proceedings of the National Academy of Sciences . 103 (8): 2794–9.
Bibcode :
2006PNAS..103.2794R .
doi :
10.1073/pnas.0510423103 .
PMC
1413797 .
PMID
16477019 .
Dai, H; Van't Veer, L; Lamb, J; He, Y. D.; Mao, M; Fine, B. M.; Bernards, R; Van De Vijver, M; Deutsch, P; Sachs, A; Stoughton, R; Friend, S (2005).
"A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients" . Cancer Research . 65 (10): 4059–66.
doi :
10.1158/0008-5472.CAN-04-3953 .
PMID
15899795 .
Lampe, J. W.; Stepaniants, S. B.; Mao, M; Radich, J. P.; Dai, H; Linsley, P. S.; Friend, S. H.; Potter, J. D. (2004).
"Signatures of environmental exposures using peripheral leukocyte gene expression: Tobacco smoke" . Cancer Epidemiology, Biomarkers & Prevention . 13 (3): 445–53.
doi :
10.1158/1055-9965.445.13.3 .
PMID
15006922 .
S2CID
7624677 .
Van 't Veer, L. J.; Dai, H; Van De Vijver, M. J.; He, Y. D.; Hart, A. A.; Bernards, R; Friend, S. H. (2003).
"Expression profiling predicts outcome in breast cancer" . Breast Cancer Research . 5 (1): 57–8.
doi :
10.1186/bcr562 .
PMC
154139 .
PMID
12559048 .
Van De Vijver, M. J.; He, Y. D.; Van't Veer, L. J.; Dai, H; Hart, A. A.; Voskuil, D. W.; Schreiber, G. J.; Peterse, J. L.; Roberts, C; Marton, M. J.; Parrish, M; Atsma, D; Witteveen, A; Glas, A; Delahaye, L; Van Der Velde, T; Bartelink, H; Rodenhuis, S; Rutgers, E. T.; Friend, S. H.; Bernards, R (2002). "A gene-expression signature as a predictor of survival in breast cancer". New England Journal of Medicine . 347 (25): 1999–2009.
doi :
10.1056/NEJMoa021967 .
hdl :
1874/15577 .
PMID
12490681 .
Lamb, J. R.; Zhang, C; Xie, T; Wang, K; Zhang, B; Hao, K; Chudin, E; Fraser, H. B.; Millstein, J; Ferguson, M; Suver, C; Ivanovska, I; Scott, M; Philippar, U; Bansal, D; Zhang, Z; Burchard, J; Smith, R; Greenawalt, D; Cleary, M; Derry, J; Loboda, A; Watters, J; Poon, R. T.; Fan, S. T.; Yeung, C; Lee, N. P.; Guinney, J; Molony, C; et al. (2011).
"Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting" . PLOS ONE . 6 (7): e20090.
Bibcode :
2011PLoSO...620090L .
doi :
10.1371/journal.pone.0020090 .
PMC
3130029 .
PMID
21750698 .
Mihich, E; Feunteun, J; Friend, S (2002). "Thirteenth annual pezcoller symposium: Focusing analytical tools on complexity in cancer". Cancer Research . 62 (13): 3883–7.
PMID
12097304 .
References
External links
International National Academics