Multiple studies have employed SimThyr for in silico research on the control of
thyroid function.[7][8]
The original version was developed to check hypotheses about the generation of
pulsatileTSH release.[9] Later and expanded versions of the software were used to develop the hypothesis of the
TSH-T3 shunt in the hypothalamus-pituitary-thyroid axis,[10] to assess the validity of calculated parameters of thyroid homeostasis (including
SPINA-GT and
SPINA-GD)[11][12] and to study
allostatic mechanisms leading to
non-thyroidal illness syndrome.[13][14]
SimThyr was also used to show that the release rate of thyrotropin is controlled by multiple factors other than
T4 and that the relation between
free T4 and TSH may be different in
euthyroidism,
hypothyroidism and
thyrotoxicosis.[15]
Public perception, reception and discussion of the software
SimThyr is
free and
open-source software. This ensures the
source code to be available, which facilitates scientific discussion and reviewing of the underlying model.[16][17] Additionally, the fact that it is freely available may result in economical benefits.[18][19]
The software provides an editor that enables users to modify most structure parameters of the information processing structure.[20] This functionality fosters simulation of several functional diseases of the thyroid and the pituitary gland. Parameter sets may be stored as MIRIAM- and
MIASE-compliant XML files.
On the other hand, the complexity of the user interface and the lack of the ability to model treatment effects have been criticized.[21]
^Berberich, Julian (13 September 2018). "Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Matlab/Simulink Files for Simulation and Sensitivity Analysis".
doi:
10.5281/zenodo.1415331. {{
cite journal}}: Cite journal requires |journal= (
help)
^
abDietrich, Johannes W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis : Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin: Logos-Verlag.
ISBN978-3897228504.
^Dietrich, Johannes W.; Midgley, John E. M.; Hoermann, Rudolf (2018). Homeostasis and Allostasis of Thyroid Function. Lausanne: Frontiers Media SA.
ISBN9782889455706.
^Hoermann, R; Pekker, MJ; Midgley, JEM; Larisch, R; Dietrich, JW (February 2020). "Triiodothyronine secretion in early thyroid failure: The adaptive response of central feedforward control". European Journal of Clinical Investigation. 50 (2): e13192.
doi:
10.1111/eci.13192.
PMID31815292.
S2CID208956920.
^Ghosh, Devleena; Mandal, Chittaranjan (2020). "Clustering Based Parameter Estimation of Thyroid Hormone Pathway". IEEE/ACM Transactions on Computational Biology and Bioinformatics. PP (1): 343–354.
doi:
10.1109/TCBB.2020.2995589.
PMID32750849.
S2CID219479222.
^DIETRICH, J. W.; TESCHE, A.; PICKARDT, C. R.; MITZDORF, U. (2004). "Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis". Cybernetics and Systems. 35 (4): 315–331.
doi:
10.1080/01969720490443354.
S2CID13421388.
^Hoermann, Rudolf; Midgley, John E. M.; Larisch, Rolf; Dietrich, Johannes W. (October 2018). "The role of functional thyroid capacity in pituitary thyroid feedback regulation". European Journal of Clinical Investigation. 48 (10): e13003.
doi:
10.1111/eci.13003.
PMID30022470.
S2CID51698223.