From Wikipedia, the free encyclopedia
Sca-1 stands for "
Stem cells
antigen -1" (official gene symbol: Ly6a). It consist of 18-kDa mouse
glycosyl
phosphatidylinositol -anchored
cell surface
protein (GPI-AP) of the
LY6
gene family .
[1] It is the common
biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
Application of Sca-1
Sca-1 has a
regenerative role in
cardiac repair: Host cells with specific Sca-1+CD31− markers arise upon
myocardial infarction , with evidence of expression of Sca-1 protein.
[2]
Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.
[3]
References
^ Holmes, Christina; Stanford, William L. (June 2007).
"Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma" . Stem Cells . 25 (6): 1339–1347.
doi :
10.1634/stemcells.2006-0644 .
PMID
17379763 .
S2CID
6514438 .
^ Wang, X; Hu, Q; Nakamura, Y; Lee, J; Zhang, G; From, AH; Zhang, J (2006).
"The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling" . Stem Cells . 24 (7): 1779–1788.
doi :
10.1634/stemcells.2005-0386 .
PMID
16614004 .
^ Bradfute, Steven B.; Graubert, Timothy A.; Goodell, Margaret A. (July 2005).
"Roles of Sca-1 in hematopoietic stem/progenitor cell function" . Experimental Hematology . 33 (7): 836–843.
doi :
10.1016/j.exphem.2005.04.001 .
PMID
15963860 .