From Wikipedia, the free encyclopedia
Chemical compound
Sarolaner
|
|
Trade names | Simparica |
---|
Other names | PF-6450567 |
---|
ATCvet code | |
---|
|
Legal status |
|
---|
|
1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
|
CAS Number | |
---|
PubChem
CID | |
---|
ChemSpider | |
---|
UNII | |
---|
KEGG | |
---|
ChEMBL | |
---|
ECHA InfoCard |
100.234.000
|
---|
|
Formula | C23H18Cl2F4N2O5S |
---|
Molar mass | 581.36 g·mol−1 |
---|
3D model (
JSmol) | |
---|
CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12
|
InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1 Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N
|
Sarolaner, sold under the brand name Simparica, is an
ectoparasiticide veterinary
medication for the treatment of
flea and
tick infestations in dogs.
[3]
[4] It is also used off-label to control
sarcoptic mange and
demodectic mange.
[4]
Sarolaner is also a component of the
combination drug Simparica Trio, which contains sarolaner,
moxidectin, and
pyrantel.
[5] It is used for prevention of
heartworm disease caused by
Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the
lone star tick,
Gulf Coast tick,
American dog tick,
black-legged tick, and
brown dog tick; and treat and control
roundworm and adult
hookworm infections.
[6]
Sarolaner is also an ingredient in feline
combination
antiparasitic Revolution Plus (or Stronghold Plus
[7]), which contains sarolaner and
selamectin and is used for prevention of
sarcoptic mange, feline
hookworms, feline
roundworms,
ear mites, and
heartworms, as well as treating and preventing
fleas and
ticks.
[8]
References
-
^
"Approved in 2020: Drugs for human use".
Health Canada. 26 July 2021. Retrieved 27 March 2024.
-
^
"Simparica". U.S.
Food and Drug Administration (FDA). Retrieved 12 December 2022.
-
^ McTier TL, Chubb N, Curtis MP, Hedges L, Inskeep GA, Knauer CS, et al. (May 2016).
"Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs" (PDF). Veterinary Parasitology. 222: 3–11.
doi:
10.1016/j.vetpar.2016.02.019.
PMID
26961590.
- ^
a
b Gollakner R.
"Sarolaner". vcahospitals.com. VCA Hospitals. Retrieved 26 June 2021.
-
^
"Simparica Trio". U.S.
Food and Drug Administration (FDA). Retrieved 12 December 2022.
-
^
"FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites". U.S.
Food and Drug Administration (FDA). 2 March 2020. Retrieved 26 June 2021.
-
^
"Stronghold Plus". European Medicines Agency. Retrieved 12 December 2022.
-
^
"Revolution Plus". U.S.
Food and Drug Administration (FDA). Retrieved 12 December 2022.
External links
-
"Sarolaner". Drug Information Portal. U.S. National Library of Medicine.