American chemist
Sarah Elizabeth Reisman is the Bren Professor of Chemistry and the Chair of Division of Chemistry and Chemical Engineering at
California Institute of Technology .
[1] She received the (2013)
Arthur C. Cope Scholar Award
[2] and the (2014)
[3]
Tetrahedron Young Investigator Award for Organic Synthesis.
[4] Her research focuses on the
total synthesis of complex
natural products and data-driven developments of asymmetric catalysis.
Early career and education
Undergraduate Studies
Reisman received a
B.A. in chemistry from
Connecticut College in 2001,
[5] conducting research in the lab of Prof.
Timo V. Ovaska
[6] on the synthesis of tetracyclic
terpenoid natural products, including
phorbol .
[7]
[8]
Graduate Studies
Reisman obtained her
Ph.D. from
Yale University
[9] in 2006, working with
John L. Wood on the total synthesis of (±)-welwitindolinone A isonitrile.
[10] Reisman's work included methodological developments towards a generalized skeleton, using nitrone cyclization and
oxindole formation as linchpin transforms.
[11]
Postdoctoral Studies
Reisman was an
NIH Postdoctoral Fellow in the lab of
Eric N. Jacobsen at
Harvard University and worked with then-graduate student
Abigail Doyle to develop an enantioselective substitution of silyl ketenes onto an alkoxy chloride via an
oxocarbenium ion using a novel
thiourea organocatalyst .
[12]
Research
Reisman began her independent career as an assistant professor at Caltech in 2008
[13] and was promoted to full professor in 2014.
[14]
The Reisman lab focuses on the synthesis of complex natural products and development of new chemical reactions, and the interplay between those two fields.
The group completed the first
enantioselective total syntheses of (–)-acetylaranotin (40 years after its isolation),
[15]
[16] (–)-maoecrystal Z,
[17] (–)-8-demethoxyrunanine, and (–)-cepharatines A, C and D.
[18] Their total synthesis of (+)-ryanodol was completed in 15 synthetic steps,
[19] a significant improvement on the previous shortest synthetic route of 35 steps developed by
Masayuki Inoue of the
University of Tokyo .
[20]
[21] In 2019, Reisman and coworkers published the first total synthesis of isoryanoid diterpene (+)-perseanol in Nature .
[22] Other completed total syntheses include natural products (+)-naseseazines A and B,
[23] (+)-salvileucalin B,
[24] (+)-psiguadial B
[25]
[26]
[27] and
(+)-pleuromutilin .
[28]
The group's reaction methodology work has focused primarily on nickel catalysis,
[29]
cycloadditions ,
[30] and opening of strained-ring precursors.
Selected Awards and Honors
Reisman was awarded the
Boehringer Ingelheim New Faculty Grant,
[44] the
Alfred P Sloan Foundation Fellowship
[45] and a 5-year
NSF CAREER Award in 2011.
[46]
References
^
"Sarah E. Reisman | Division of Chemistry and Chemical Engineering" . cce.caltech.edu . Retrieved 2021-04-28 .
^
"Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire" (PDF) . www.chem.purdue.edu .
^
Tetrahedron .
^
"The Reisman Group" . reismangroup.caltech.edu . Retrieved 2018-07-26 .
^
"Student Hosted Colloquia: Professor Sarah Reisman, Caltech | Department of Chemistry" . chemistry.stanford.edu . Retrieved 2021-04-28 .
^
"sarah reisman, Timo V. Ovaska – Google Search" . www.google.com . Retrieved 2021-04-28 .
^
"Ovaska Research Group" . Connecticut College . Retrieved 2018-07-26 .
^ "Bright Young Minds: Meet 10 scientists who are making their mark". Science News . 188 (7): 20–26. 2015-09-23.
doi :
10.1002/scin.2015.188007018 .
ISSN
0036-8423 .
^ Trager2020-04-29T14:00:00+01:00, Rebecca.
"Chemists amid coronavirus: Sarah Reisman" . Chemistry World . Retrieved 2021-04-28 . {{
cite web }}
: CS1 maint: numeric names: authors list (
link )
^ Reisman, Sarah E.; Ready, Joseph M.; Weiss, Matthew M.; Hasuoka, Atsushi; Hirata, Makoto; Tamaki, Kazuhiko; Ovaska, Timo V.; Smith, Catherine J.; Wood, John L. (February 2008).
"Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile" (PDF) . Journal of the American Chemical Society . 130 (6): 2087–2100.
doi :
10.1021/ja076663z .
ISSN
0002-7863 .
PMID
18198870 .
^
"Total Synthesis of ()-Welwitindolinone A Isonitrile" (PDF) . J.A.C.S. Communications .
^ Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N. (June 2008).
"Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions" . Journal of the American Chemical Society . 130 (23): 7198–7199.
doi :
10.1021/ja801514m .
ISSN
0002-7863 .
PMC
2574628 .
PMID
18479086 .
^
"Caltech Faculty Receive Named Professorships" . Division of Chemistry and Chemical Engineering . 9 October 2020. Retrieved 2021-04-28 .
^
"Organic chemistry colloquium" . UDaily . Retrieved 2021-04-28 .
^ Codelli, Julian A.; Puchlopek, Angela L. A.; Reisman, Sarah E. (2011-10-28).
"Enantioselective Total Synthesis of (−)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine" . Journal of the American Chemical Society . 134 (4): 1930–1933.
doi :
10.1021/ja209354e .
ISSN
0002-7863 .
PMC
3271125 .
PMID
22023250 .
^ Drahl, Carmen.
"Alkaloid Acetylaranotin Made After 40-Year Quest | Chemical & Engineering News" . cen.acs.org . Retrieved 2018-07-29 .
^ Cha, J. Y.; Yeoman, J. T. S.; Reisman, S. E. (2011-11-18). "Synthesis of (-)-Maoecrystal Z". Synfacts . 2011 (12): 14964–7.
doi :
10.1055/s-0031-1289337 .
ISSN
1861-1958 .
PMID
21877709 .
^ Ley, Steven V.; Frost, James R. (2011-12-19). "Synthesis of (–)-8-Demethoxyrunanine and (–)-Cepharatines A, C and D". Synfacts . 8 (1): 0014.
doi :
10.1055/s-0031-1289924 .
ISSN
1861-1958 .
S2CID
100429449 .
^ Chuang, Kangway V.; Xu, Chen; Reisman, Sarah E. (2016-08-26).
"A 15-step synthesis of (+)-ryanodol" . Science . 353 (6302): 912–915.
Bibcode :
2016Sci...353..912C .
doi :
10.1126/science.aag1028 .
ISSN
0036-8075 .
PMC
5505075 .
PMID
27563092 .
^ Lemonick, Sam.
"A Simpler Way To Make A Complicated Molecule" . Forbes . Retrieved 2018-07-26 .
^ Pei-Qiang., Huang (2016). Efficiency in natural products total synthesis . [Place of publication not identified]: John Wiley & Sons. p. 132.
ISBN
9781118940204 .
OCLC
1046102804 .
^ Han, Arthur; Tao, Yujia; Reisman, Sarah E. (September 2019).
"A 16-step synthesis of the isoryanodane diterpene (+)-perseanol" . Nature . 573 (7775): 563–567.
Bibcode :
2019Natur.573..563H .
doi :
10.1038/s41586-019-1580-x .
ISSN
1476-4687 .
PMC
7123484 .
PMID
31554978 .
^ Kieffer, Madeleine E.; Chuang, Kangway V.; Reisman, Sarah E. (2013-04-03).
"Copper-Catalyzed Diastereoselective Arylation of Tryptophan Derivatives: Total Synthesis of (+)-Naseseazines A and B" . Journal of the American Chemical Society . 135 (15): 5557–5560.
doi :
10.1021/ja4023557 .
ISSN
0002-7863 .
PMC
3662218 .
PMID
23540731 .
^ Levin, S.; Nani, R. R.; Reisman, S. E. (2011-05-19).
"Enantioselective Synthesis of (+)-Salvileucalin B" (PDF) . Journal of the American Chemical Society . 133 (4): 774–6.
doi :
10.1021/ja110192b .
PMID
21174417 .
^ Chapman, Lauren M.; Beck, Jordan C.; Wu, Linglin; Reisman, Sarah E. (2016-08-02).
"Enantioselective Total Synthesis of (+)-Psiguadial B" (PDF) . Journal of the American Chemical Society . 138 (31): 9803–9806.
doi :
10.1021/jacs.6b07229 .
ISSN
0002-7863 .
PMID
27452034 .
^ Halford, Bethany.
"An enantioselective synthesis of (+)-psiguadial B | Chemical & Engineering News" . cen.acs.org . Retrieved 2018-07-29 .
^ Carreira, Erick M.; Nannini, Leonardo J. (2016-09-19). "Synthesis of (+)-Psiguadial B". Synfacts . 12 (10): 1003.
doi :
10.1055/s-0036-1589189 .
ISSN
1861-1958 .
S2CID
100560691 .
^ Farney, Elliot P.; Feng, Sean S.; Schäfers, Felix; Reisman, Sarah E. (2018-01-31).
"Total Synthesis of (+)-Pleuromutilin" . Journal of the American Chemical Society . 140 (4): 1267–1270.
doi :
10.1021/jacs.7b13260 .
ISSN
0002-7863 .
PMC
5988231 .
PMID
29323492 .
^ Cherney, Alan H.; Kadunce, Nathaniel T.; Reisman, Sarah E. (2013-05-22).
"Catalytic Asymmetric Reductive Acyl Cross-Coupling: Synthesis of Enantioenriched Acyclic α,α-Disubstituted Ketones" . Journal of the American Chemical Society . 135 (20): 7442–7445.
doi :
10.1021/ja402922w .
ISSN
0002-7863 .
PMID
23634932 .
^ Repka, Lindsay M.; Ni, Jane; Reisman, Sarah E. (2010-10-20).
"Enantioselective Synthesis of Pyrroloindolines by a Formal [3 + 2] Cycloaddition Reaction" . Journal of the American Chemical Society . 132 (41): 14418–14420.
doi :
10.1021/ja107328g .
ISSN
0002-7863 .
PMC
3222144 .
PMID
20873714 .
^
"Inhoffen Medal" . Helmholtz Centre for Infection Research . Retrieved 2024-03-28 .
^
"2020 National Award Recipients Citations" . American Chemical Society . Retrieved 2020-09-06 .
^
"Winner of the Women in Chemistry Award has been announced! – Thieme Chemistry – Georg Thieme Verlag KG" . Thieme . Retrieved 2020-09-06 .
^
"Lecture: "Necessity is the Mother of Invention: Natural Products and the Chemistry they Inspire" " . Mount Holyoke College . 2018-11-12. Retrieved 2018-11-21 .
^
"Gift Enables Transformative Advances in Health Care – Caltech Campaign" . Caltech Campaign . 2018-03-01. Retrieved 2018-11-17 .
^ "Bright Young Minds: Meet 10 scientists who are making their mark". Science News . 188 (7): 20–26. 2015-09-23.
doi :
10.1002/scin.2015.188007018 .
ISSN
0036-8423 .
^
Tetrahedron Young Investigator Award .
^
"Arthur C. Cope Scholar Awards – American Chemical Society" . American Chemical Society . Retrieved 2018-07-29 .
^ Drahl, Carmen.
"Arthur C. Cope Scholar: Sarah E. Reisman | Chemical & Engineering News" . cen.acs.org . Retrieved 2018-07-26 .
^
"Pasadena Now " Society Names Caltech Chemist Sarah Reisman a Rising Star | Pasadena California, Hotels, CA Real Estate, Restaurants, City Guide... - Pasadena.com" . www.pasadenanow.com . Retrieved 2018-07-29 .
^
"Women Chemists Committee announces inaugural Rising Star Award and winners – American Chemical Society" . American Chemical Society . Retrieved 2018-07-29 .
^
"Sarah Reisman, Cottrell Scholar Award – Research Corporation for Science Advancement" . Research Corporation for Science Advancement . 18 April 2012. Retrieved 2018-07-31 .
^
"Novartis Early Career Award in Organic Chemistry 2012 :: News :: ChemistryViews" . www.chemistryviews.org . 3 December 2012. Retrieved 2018-07-29 .
^ "Boehringer Ingelheim New Investigator Award in organischer Chemie: A. G. Doyle / Boehringer Ingelheim New Faculty Grant: S. E. Reisman / GDCh-Preis für Schriftsteller und Journalisten: V. Köster". Angewandte Chemie . 124 (11): 2591. 2012-02-28.
Bibcode :
2012AngCh.124.2591. .
doi :
10.1002/ange.201201128 .
ISSN
0044-8249 .
^
"Past Fellows" . sloan.org . Retrieved 2018-07-29 .
^
"NSF Award Search: Award#1057143 – CAREER: New Strategies and Methods for the Total Synthesis of Propellane Natural Products" . www.nsf.gov . Retrieved 2018-07-29 .
International National Academics