Sabin Vaccine Institute (
SAY -bin ), located in Washington, D.C., is a nonprofit organization promoting global
vaccine development, availability, and use. Through its work, Sabin hopes to reduce human suffering by preventing the spread of
vaccine-preventable ,
communicable disease in humans through
herd immunity and mitigating the poverty caused by these diseases.
Background
Founded in 1993
[3]
[4]
[5] in honor of
Albert B. Sabin , creator of the oral
polio vaccine , Sabin works to reduce "human suffering from vaccine-preventable and
neglected tropical diseases (NTDs) ."
[1]
[2] The organization endeavors to reach its goal via its three main programs: Sabin Vaccine Development, the
Global Network for Neglected Tropical Diseases , and Vaccine Advocacy and Education.
[6] Through its Product Development Partnership (PDP), Sabin has worked with organizations such as
King Saud University ,
[7] Texas Children's Hospital Center,
[8]
International Vaccine Institute ,
[9] and
George Washington University School of Medicine & Health Sciences
[10] toward its goals, with funding and support from the
Bill & Melinda Gates Foundation ,
[10]
[11] the
National Institute of Allergy and Infectious Diseases ,
[12] the
Dutch Ministry of Foreign Affairs ,
[13] the
Brazilian Ministry of Health
[13] and other benefactors.
Vaccine development and research
In 2012, Sabin partnered with International Vaccine Institute to combine their research, development, and promotion efforts in Asia, Africa, and the Americas.
[9]
Sabin is currently working on multiple vaccines for humans
[1] including vaccines for
Hookworm infection (Na -GST-1, Na -APR-1),
[10]
[13]
[14]
[15]
Schistosomiasis (Sm -TSP-2),
[16]
[17]
[18]
[19]
Chagas disease (Tc 24, TSA-1),
[8]
[20]
[21]
Leishmaniasis (Ld -NH36, PdSP15),
[22]
[23]
[24]
severe acute respiratory syndrome (SARS) /
Middle East respiratory syndrome (MERS) (Pan-β-CoVax),
[25]
[26]
[27]
Soil-transmitted helminthiasis (STH),
[28]
[29] and
Onchocerciasis (Ov-103 , Ov-RAL-2 ).
[30]
[31]
[32]
[33]
Neglected tropical diseases
In 2006, Sabin co-founded the
Global Network for Neglected Tropical Diseases in order "to raise the awareness, political will and funding necessary to control and eliminate the most common NTDs."
[34] Through its work on NTDs, Sabin hopes to reduce poverty caused by these diseases as many of them have been shown to adversely affect "childhood cognitive development among the poor, thereby reinforcing poverty."
[35]
Advocacy and education
Sabin works with experts and organizations from around the world to advance knowledge of both infectious diseases and the vaccines that can prevent them. Through the International Association of Immunization Managers (IAIM) Network, Sabin arranges international forums to improve the success rates of immunization programs.
[6] Sabin serves as the secretariat for the
Coalition against Typhoid , and its mission is to raise awareness of
typhoid and
salmonellosis .
[36]
Board of directors
Axel Hoos (chairman)
Amy Finan (ex officio trustee)
Peter L. Thoren (vice chairman)
Wendy Commins Holman
Kenneth Kelley
Paul Maddon
Michael W. Marine
Regina Rabinovich
Philip K. Russell (past chairman)
Gold medal award
First awarded in 1994, the
Albert B. Sabin Gold Medal is presented by Sabin each year to one or more persons who have made a major contribution to the field of vaccinology or related fields. The award is given in honor of the work of
Albert B. Sabin .
[37] Past recipients of the award include
Samuel L. Katz (2003),
Joseph L. Melnick (1996), and
Ruth S. Nussenzweig (2008).
[38]
References
^
a
b
c
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^
a
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^
a
b
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^
a
b
"The Legacy of Albert B. Sabin" . Sabin . October 2012. Retrieved 6 September 2017 .
^
a
b
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^
a
b
"Immunization Manager Network" . Sabin . 28 April 2017. Archived from
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^
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^
a
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^ Dipali Pathak (30 August 2016).
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^
a
b
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^
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^
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^ Tebeje, Biniam Mathewos; Harvie, Marina; You, Hong; Loukas, Alex; McManus, Donald P. (30 September 2016).
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^ Merrifield, Maureen; Hotez, Peter J.; Beaumier, Coreen M.; Gillespie, Portia; Strych, Ulrich; Hayward, Tara; Bottazzi, Maria Elena (3 June 2016).
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^
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^
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the original on 18 September 2017. Retrieved 18 September 2017 .
^ Beaumier, Coreen M.; Gillespie, Portia M.; Strych, Ulrich; Hayward, Tara; Hotez, Peter J.; Bottazzi, Maria Elena (3 June 2016).
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ISSN
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PMID
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^
"Chagas" . Sabin . 28 April 2017. Archived from
the original on 12 July 2017. Retrieved 18 September 2017 .
^ Gillespie, Portia M.; Beaumier, Coreen M.; Strych, Ulrich; Hayward, Tara; Hotez, Peter J.; Bottazzi, Maria Elena (3 June 2016).
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^ Asojo, Oluwatoyin A.; Kelleher, Alan; Liu, Zhuyun; Pollet, Jeroen; Hudspeth, Elissa M.; Rezende, Wanderson C.; Groen, Mallory Jo; Seid, Christopher A.; Abdeladhim, Maha; Townsend, Shannon; Castro, Waldione de; Mendes-Sousa, Antonio; Bartholomeu, Daniella Castanheira; Fujiwara, Ricardo Toshio; Bottazzi, Maria Elena; Hotez, Peter J.; Zhan, Bin; Oliveira, Fabiano; Kamhawi, Shaden; Valenzuela, Jesus G. (9 March 2017).
"Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis" . PLOS Neglected Tropical Diseases . 11 (3): e0005374.
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ISSN
1935-2735 .
PMC
5344329 .
PMID
28278244 .
^
"Leishmaniasis" . Sabin . 28 April 2017. Archived from
the original on 12 July 2017. Retrieved 18 September 2017 .
^ Jiang, Shibo; Bottazzi, Maria Elena; Du, Lanying; Lustigman, Sara; Tseng, Chien-Te Kent; Curti, Elena; Jones, Kathryn; Zhan, Bin; Hotez, Peter J (December 2012).
"Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome" .
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^ Chen, Wen-Hsiang; Du, Lanying; Chag, Shivali M.; Ma, Cuiqing; Tricoche, Nancy; Tao, Xinrong; Seid, Christopher A.; Hudspeth, Elissa M.; Lustigman, Sara; Tseng, Chien-Te K.; Bottazzi, Maria Elena; Hotez, Peter J.; Zhan, Bin; Jiang, Shibo (2014).
"Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate" .
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doi :
10.4161/hv.27464 .
ISSN
2164-554X .
PMC
4130269 .
PMID
24355931 .
^
"SARS/MERS" . Sabin . 28 April 2017. Archived from
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^ Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J (2014).
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^
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^
"Onchocerciasis" . Sabin . 28 April 2017. Archived from
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^ Hotez, Peter J.; Bottazzi, Maria Elena; Zhan, Bin; Makepeace, Benjamin L.; Klei, Thomas R.; Abraham, David; Taylor, David W.; Lustigman, Sara (29 January 2015).
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^
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^
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^
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^ Hotez, Peter J (16 December 2014).
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^
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^
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^
"The Albert B. Sabin Gold Medal Award" . Sabin . 12 September 2012. Archived from
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