From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Metalloreductase STEAP2 is an
enzyme that in humans is encoded by the STEAP2
gene .
[5]
[6]
[7]
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the
Golgi complex , the plasma membrane, and the vesicular tubular structures in the
cytosol .
A highly similar protein in mouse has both ferri reductase and cupric
reductase activity, and stimulates the cellular uptake of both iron and copper
in vitro. Increased transcriptional expression of the human gene is associated with
prostate cancer progression. Alternate transcriptional splice variants, encoding different
isoforms , have been characterized.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000157214 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000015653 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000).
"Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes" . Genome Res . 9 (12): 1198–203.
doi :
10.1101/gr.9.12.1198 .
PMC
310991 .
PMID
10613842 .
^ Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002).
"Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer" . J Biol Chem . 277 (39): 36689–96.
doi :
10.1074/jbc.M202414200 .
PMID
12095985 .
^
a
b
"Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2" .
Further reading
Denoeud F, Kapranov P, Ucla C, et al. (2007).
"Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions" . Genome Res . 17 (6): 746–59.
doi :
10.1101/gr.5660607 .
PMC
1891335 .
PMID
17567994 .
Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006).
"The Steap proteins are metalloreductases" . Blood . 108 (4): 1388–94.
doi :
10.1182/blood-2006-02-003681 .
PMC
1785011 .
PMID
16609065 .
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005).
"Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer" . Oncogene . 24 (31): 4934–45.
doi :
10.1038/sj.onc.1208677 .
PMID
15897894 .
Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005).
"ACRATA: a novel electron transfer domain associated to apoptosis and cancer" . BMC Cancer . 4 : 98.
doi :
10.1186/1471-2407-4-98 .
PMC
546010 .
PMID
15623366 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Porkka KP, Helenius MA, Visakorpi T (2002).
"Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate" . Lab. Invest . 82 (11): 1573–82.
doi :
10.1097/01.lab.0000038554.26102.c6 .
PMID
12429817 .