From Wikipedia, the free encyclopedia
In
genetics , rs6311 is a gene variation—a
single nucleotide polymorphism (SNP)—in the human
HTR2A
gene that codes for the
5-HT2A
receptor . 5-HT2A is a
neuroreceptor , and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the
Temperament and Character Inventory
[1]
[2]
[3]
[4]
or with a psychological task measuring impulsive behavior.
[5]
The SNP has also been investigated in
rheumatology studies.
[6]
[7]
Some research studies may refer to this gene variation as a C/T SNP,
[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.
[8]
[9]
[10]
As of 2008
[update] ,
meta-analysis of research studies indicates that people with the A-
allele may have slightly elevated risk of
schizophrenia .
[11]
rs6313 ,
rs6314 , and
rs7997012 are other investigated SNPs in the HTR2A gene.
References
^ Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS (January 2004). "Serotonergic genes and personality traits in the Korean population". Neurosci. Lett . 354 (1): 2–5.
doi :
10.1016/S0304-3940(03)00753-5 .
PMID
14698468 .
S2CID
22448256 .
^
a
b Giegling I, Hartmann AM, Möller HJ, Rujescu D (November 2006). "Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene".
Journal of Affective Disorders . 96 (1–2): 75–81.
doi :
10.1016/j.jad.2006.05.016 .
PMID
16814396 .
^ Unschuld PG, Ising M, Erhardt A, Lucae S, Kloiber S, Kohli M, Salyakina D, Welt T, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME (June 2007). "Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder".
Am J Med Genet B . 144B (4): 424–429.
doi :
10.1002/ajmg.b.30412 .
PMID
17440930 .
S2CID
10374372 .
^ Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C, Rujescu D (August 2007). "5-HT2A SNPs and the Temperament and Character Inventory".
Progress in Neuro-Psychopharmacology and Biological Psychiatry . 31 (6): 1275–1281.
doi :
10.1016/j.pnpbp.2007.05.008 .
PMID
17590256 .
S2CID
2646380 .
^ Nomura M, Kusumi I, Kaneko M, Masui T, Daiguji M, Ueno T, Koyama T, Nomura Y (July 2006). "Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior". Psychopharmacology . 187 (1): 30–35.
doi :
10.1007/s00213-006-0398-z .
PMID
16767413 .
S2CID
12155339 .
^ Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, Canturk F (May 2008). "Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility".
Rheumatology International . 28 (7): 685–691.
doi :
10.1007/s00296-008-0525-8 .
PMID
18196244 .
S2CID
29817254 .
^ Kling A, Seddighzadeh M, Ärlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L (2007).
"Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis" .
Ann. Rheum. Dis. 67 (8): 1111–5.
doi :
10.1136/ard.2007.074948 .
PMID
18006541 .
S2CID
3081132 .
^ Reynolds CA, Jansson M, Gatz M, Pedersen NL (January 2006). "Longitudinal change in memory performance associated with HTR2A polymorphism".
Neurobiology of Aging . 27 (1): 150–154.
doi :
10.1016/j.neurobiolaging.2004.12.009 .
PMID
16298250 .
S2CID
32745716 .
^ Halder I, Muldoon MF, Ferrell RE, Manuck SB (December 2007).
"Serotonin Receptor 2A (HTR2A ) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome" .
Metabolic Syndrome and Related Disorders . 5 (4): 323–330.
doi :
10.1089/met.2007.0008 .
PMC
3237193 .
PMID
18370802 .
^ Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Bascaran MT, Martinez-Barrondo S, Florez G, Sotomayor E, Paredes B, Alvarez C, San Narciso G, Carreño E, Bombin I, Alvarez V, Coto E, Fernandez JM, Bousoño M, Bobes J (April 2008). "Association study between obsessive–compulsive disorder and serotonergic candidate genes".
Progress in Neuro-Psychopharmacology and Biological Psychiatry . 32 (3): 765–770.
doi :
10.1016/j.pnpbp.2007.12.005 .
PMID
18191318 .
S2CID
35024576 .
^
"Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6311" .
Schizophrenia Research Forum . Retrieved 2008-06-10 .