From Wikipedia, the free encyclopedia
Chemical compound
Ro20-8552
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Legal status |
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8-chloro-5-(2-fluorophenyl)-7-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
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PubChem
CID | |
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ChemSpider | |
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ChEMBL | |
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Formula | C16H12ClFN2O |
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Molar mass | 302.73 g·mol−1 |
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3D model (
JSmol) | |
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CC1=CC2=C(C=C1Cl)NC(=O)CN=C2C3=CC=CC=C3F
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InChI=1S/C16H12ClFN2O/c1-9-6-11-14(7-12(9)17)20-15(21)8-19-16(11)10-4-2-3-5-13(10)18/h2-7H,8H2,1H3,(H,20,21) Key:GANKBGRUGXCJBG-UHFFFAOYSA-N
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Ro20-8552 is a
benzodiazepine derivative with
sedative and
anxiolytic effects, which has been sold as a
designer drug.
[1]
[2]
See also
References
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^ Zhang W, Koehler KF, Harris B, Skolnick P, Cook JM (March 1994). "Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors". Journal of Medicinal Chemistry. 37 (6): 745–57.
doi:
10.1021/jm00032a007.
PMID
8145224.
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^ Catalani V, Botha M, Corkery JM, Guirguis A, Vento A, Scherbaum N, Schifano F (July 2021).
"The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity". Pharmaceuticals. 14 (8): 720.
doi:
10.3390/ph14080720.
hdl:
2299/24928.
PMC
8398354.
PMID
34451817.
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Alcohols | |
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Barbiturates | |
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Benzodiazepines | |
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Carbamates | |
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Flavonoids | |
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Imidazoles | |
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Kava constituents | |
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Monoureides | |
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Neuroactive steroids | |
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Nonbenzodiazepines | |
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Phenols | |
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Piperidinediones | |
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Pyrazolopyridines | |
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Quinazolinones | |
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Volatiles/
gases | |
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Others/unsorted |
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3-Hydroxybutanal
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α-EMTBL
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AA-29504
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Alogabat
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Avermectins (e.g.,
ivermectin)
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lithium bromide,
potassium bromide,
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Chloralose
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Darigabat
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DEABL
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Deuterated etifoxine
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Dihydroergolines (e.g.,
dihydroergocryptine,
dihydroergosine,
dihydroergotamine,
ergoloid (dihydroergotoxine))
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DS2
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Efavirenz
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Etazepine
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Etifoxine
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flufenamic acid,
mefenamic acid,
niflumic acid,
tolfenamic acid)
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Fluoxetine
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Flupirtine
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Hopantenic acid
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KRM-II-81
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Lanthanum
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Lavender oil
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4-O-methylhonokiol,
honokiol,
magnolol,
obovatol)
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Loreclezole
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Menthyl isovalerate (validolum)
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Monastrol
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Niacinamide
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Org 25,435
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Propanidid
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Retigabine (ezogabine)
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trional)
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borneol)
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Valerian constituents (e.g.,
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valerenol)
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