Rho GTPase activating protein 21 is a
protein that in humans is encoded by the ARHGAP21
gene.
[5]
Function
ARHGAP21 functions preferentially as a
GTPase-activating protein (GAP) for
CDC42 (MIM 116952) and regulates the
ARP2/3 complex (MIM 604221) and
F-actin dynamics at the
Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]). There is little scientific literature on ARHGAP21, but recent reviews highlighted that it plays an important role in cytoskeletal processes in cancer, substance transport within the cell, and insulin secretion [6]
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Rosa LRO; Soares, G. M.; Silveira, L. R.; Boschero, A. C.; Barbosa-Sampaio HCL (2018). "ARHGAP21 as a master regulator of multiple cellular processes". Journal of Cellular Physiology. 233 (11): 8477–8481.
doi:
10.1002/jcp.26829.
PMID29856495.
S2CID46919924.
Further reading
Bassères DS, Tizzei EV, Duarte AA, Costa FF, Saad ST (2002). "ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein". Biochem. Biophys. Res. Commun. 294 (3): 579–85.
doi:
10.1016/S0006-291X(02)00514-4.
PMID12056806.
Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P (2005). "Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics". Nat. Cell Biol. 7 (4): 353–64.
doi:
10.1038/ncb1244.
PMID15793564.
S2CID37000096.