Regression in medicine is the partial or complete reversal of a disease's signs and symptoms.
- Clinically, regression generally refers to a decrease in severity of symptoms without completely disappearing. At a later point, symptoms may return. These symptoms are then called recidive.
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- In cancer, regression refers to a specific decrease in the size or extent of a tumour. [2] In histopathology, histological regression is one or more areas within a tumor in which neoplastic cells have disappeared or decreased in number. [3] In melanomas, this means complete or partial disappearance from areas of the dermis (and occasionally from the epidermis), which have been replaced by fibrosis, accompanied by melanophages, new blood vessels, and a variable degree of inflammation. [3]
References
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^ Santos, Marisa D.; Silva, Cristina; Rocha, Anabela; Nogueira, Carlos; Castro-Poças, Fernando; Araujo, António; Matos, Eduarda; Pereira, Carina; Medeiros, Rui; Lopes, Carlos (2017).
"Predictive clinical model of tumor response after chemoradiation in rectal cancer". Oncotarget. 8 (35): 58133–58151.
doi:
10.18632/oncotarget.19651.
ISSN
1949-2553.
PMC
5601639.
PMID
28938543.
- Figure 3- available via license: Creative Commons Attribution 3.0 Unported - ^ "Regression". NCI Dictionary of Cancer Terms. National Cancer Institute. Retrieved 31 August 2017.
- ^ a b Ribero, Simone; Gualano, Maria Rosaria; Osella-Abate, Simona; Scaioli, Giacomo; Bert, Fabrizio; Sanlorenzo, Martina; Balagna, Elena; Fierro, Maria Teresa; Macripò, Giuseppe; Sapino, Anna; Siliquini, Roberta; Quaglino, Pietro (2015). "Association of Histologic Regression in Primary Melanoma With Sentinel Lymph Node Status". JAMA Dermatology. 151 (12): 1301–1307. doi: 10.1001/jamadermatol.2015.2235. ISSN 2168-6068. PMID 26332402.
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