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Chemical compound
Ravuconazole
ATC code
4-[2-[(2R ,3R )-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
CAS Number
PubChem
CID
ChemSpider
UNII
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (
EPA )
Formula C 22 H 17 F 2 N 5 O S
Molar mass 437.47 g·mol−1 3D model (
JSmol )
C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30,11-29-13-26-12-27-29)18-7-6-17(23)8-19(18)24/h2-8,10,12-14,30H,11H2,1H3/t14-,22+/m0/s1
N Key:OPAHEYNNJWPQPX-RCDICMHDSA-N
N
N Y
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Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent
triazole
antifungal , the development of which was discontinued in 2007.
[1] The drug has shown to have a similar spectrum of activity to
voriconazole , with an increased half-life.
[2] However, ravuconazole has limited activity against species of
Fusarium ,
Scedosporium , and
Zygomycetes .
[3]
[4]
See also
References
^
"Ravuconazole" . AdisInsight . Springer Nature Switzerland AG. Retrieved 12 November 2017 .
^ Pasqualotto AC, Denning DW.
"Ravuconazole" . The Aspergillus Website . Retrieved 18 February 2010 .
^ Pasqualotto AC, Thiele KO, Goldani LZ (February 2010). "Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole". Current Opinion in Investigational Drugs . 11 (2): 165–174.
PMID
20112166 .
^ Pfaller MA, Messer SA, Hollis RJ, Jones RN (April 2002).
"Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000" . Antimicrobial Agents and Chemotherapy . 46 (4): 1032–1037.
doi :
10.1128/AAC.46.4.1032-1037.2002 .
PMC
127116 .
PMID
11897586 .
External links
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