From Wikipedia, the free encyclopedia
Ravi Iyengar , is a principal investigator at The
Mount Sinai Medical Center .
[1]
[2]
Trained as a
biochemist , Iyengar studies
cellular signaling networks using both experiments and computer simulations. His laboratory focuses on how cell signals are routed and processed through cellular signaling networks within cells to discover new drug targets for complex diseases.
[3]
[4]
[5] He has published more than 100 primary papers, 92 reviews and is the editor of 6 books.
Biography
Iyengar earned both an undergraduate degree in Chemistry and Physics in 1971 and a master's degree in
Biophysics in 1973 from the
University of Mumbai in
India . He completed his Ph.D. in Biophysical Sciences at the
University of Houston in 1977. He joined
Baylor College of Medicine in 1977 as a postdoctoral fellow and rose to assistant and then associate professor. In 1986, he joined the Department of Pharmacology at The Mount Sinai Medical Center as an associate professor. In 1999, he was appointed chairman of the Department of Pharmacology at Mount Sinai, and in 2001 he was named Mount Sinai's Dorothy H. and Lewis Rosenstiel Professor and chair of the Department of Pharmacology and Biological Chemistry. He stepped down from his position as chair in January 2014.
Iyengar served as the dean of research for The Mount Sinai School of Medicine from 2002 to 2004.
In 2004, Iyengar was elected fellow of the
American Association for the Advancement of Science .
[6] Additional honors include:
Iyengar holds Patent No. 20080261820: Methods to Analyze Biological Networks.
[7]
Research grants
Structure and Function of Signal Transducing Components, 5R01DK03876-21,
National Institute of Diabetes and Digestive and Kidney Diseases
Dynamics Underlying Tissue Integrity, 1R01DK087650-01, National Institute of Diabetes and Digestive Diseases and Kidney Diseases
[8]
Systems Biology Center in New York, 5P50GM071558-03, National Institute of General Medical Sciences
[9]
Functions of Regulatory Motifs in Signaling Networks, 5R01GM054508-21, National Institute of General Medical Sciences
[10]
Modeling Cell Regulatory Networks, 5R01GM072853-04, National Institute of General Medical Sciences
[11]
Books
Heterotrimeric G Proteins, Volume 237 (Methods in Enzymology) . John N. Abelson, Melvin I. Simon, Ravi Iyengar, editors. Academic Press; 1st edition (June 28, 1994)
ISBN
0-12-182138-2
Heterotrimeric G-Protein Effectors, Volume 238 (Methods in Enzymology) . John N. Abelson, Melvin I. Simon, Ravi Iyengar, Editors. Academic Press; 1st Edition (September 1994)
ISBN
0-12-182139-0
G Protein Pathways, Part A: Receptors, Volume 343 (Methods in Enzymology) . Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001)
ISBN
0-12-182244-3
G Protein Pathways, Part B: G Proteins and Their Regulators, Volume 344 (Methods in Enzymology) . Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (December 2001)
ISBN
0-12-182245-1
G Protein Pathways, Part C: Effector Mechanisms, Volume 345 (Methods in Enzymology) . Ravi Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001)
ISBN
0-12-182246-X
Publications
Partial list:
Ram, P. T.; Horvath, C. M.; Iyengar, R (2000). "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein". Science . 287 (5450): 142–4.
Bibcode :
2000Sci...287..142R .
doi :
10.1126/science.287.5450.142 .
PMID
10615050 .
Jordan, J. D.; Landau, E. M.; Iyengar, R (2000).
"Signaling networks: The origins of cellular multitasking" . Cell . 103 (2): 193–200.
doi :
10.1016/s0092-8674(00)00112-4 .
PMC
3619409 .
PMID
11057893 .
Bhalla, U. S.; Ram, P. T.; Iyengar, R (2002). "MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network". Science . 297 (5583): 1018–23.
Bibcode :
2002Sci...297.1018B .
doi :
10.1126/science.1068873 .
PMID
12169734 .
S2CID
9516873 .
Jordan, J. D.; He, J. C.; Eungdamrong, N. J.; Gomes, I; Ali, W; Nguyen, T; Bivona, T. G.; Philips, M. R.; Devi, L. A.; Iyengar, R (2005).
"Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII" . Journal of Biological Chemistry . 280 (12): 11413–21.
doi :
10.1074/jbc.M411521200 .
PMID
15657046 .
Ma'Ayan, A; Blitzer, R. D.; Iyengar, R (2005).
"Toward predictive models of mammalian cells" . Annual Review of Biophysics and Biomolecular Structure . 34 : 319–49.
doi :
10.1146/annurev.biophys.34.040204.144415 .
PMC
3035045 .
PMID
15869393 .
Ma'Ayan, A; Jenkins, S. L.; Neves, S; Hasseldine, A; Grace, E; Dubin-Thaler, B; Eungdamrong, N. J.; Weng, G; Ram, P. T.; Rice, J. J.; Kershenbaum, A; Stolovitzky, G. A.; Blitzer, R. D.; Iyengar, R (2005).
"Formation of regulatory patterns during signal propagation in a Mammalian cellular network" . Science . 309 (5737): 1078–83.
Bibcode :
2005Sci...309.1078M .
doi :
10.1126/science.1108876 .
PMC
3032439 .
PMID
16099987 .
Moriarty, T. M.; Sealfon, S. C.; Carty, D. J.; Roberts, J. L.; Iyengar, R; Landau, E. M. (1989).
"Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins" . The Journal of Biological Chemistry . 264 (23): 13524–30.
doi :
10.1016/S0021-9258(18)80028-X .
PMID
2474532 .
Eungdamrong, N. J.; Iyengar, R (2007).
"Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi" . Biophysical Journal . 92 (3): 808–15.
Bibcode :
2007BpJ....92..808E .
doi :
10.1529/biophysj.106.093104 .
PMC
1779960 .
PMID
17098795 .
Zaidel-Bar, R; Itzkovitz, S; Ma'Ayan, A; Iyengar, R; Geiger, B (2007).
"Functional atlas of the integrin adhesome" . Nature Cell Biology . 9 (8): 858–67.
doi :
10.1038/ncb0807-858 .
PMC
2735470 .
PMID
17671451 .
Lipshtat, A; Purushothaman, S. P.; Iyengar, R; Ma'Ayan, A (2008).
"Functions of bifans in context of multiple regulatory motifs in signaling networks" . Biophysical Journal . 94 (7): 2566–79.
arXiv :
0711.4937 .
Bibcode :
2008BpJ....94.2566L .
doi :
10.1529/biophysj.107.116673 .
PMC
2267139 .
PMID
18178648 .
Bromberg, K. D.; Ma'Ayan, A; Neves, S. R.; Iyengar, R (2008).
"Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth" . Science . 320 (5878): 903–9.
Bibcode :
2008Sci...320..903B .
doi :
10.1126/science.1152662 .
PMC
2776723 .
PMID
18487186 .
Neves, S. R.; Tsokas, P; Sarkar, A; Grace, E. A.; Rangamani, P; Taubenfeld, S. M.; Alberini, C. M.; Schaff, J. C.; Blitzer, R. D.; Moraru, I. I.; Iyengar, R (2008).
"Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks" . Cell . 133 (4): 666–80.
doi :
10.1016/j.cell.2008.04.025 .
PMC
2728678 .
PMID
18485874 .
Bhalla, U. S.; Iyengar, R (1999). "Emergent properties of networks of biological signaling pathways". Science . 283 (5400): 381–7.
Bibcode :
1999Sci...283..381B .
doi :
10.1126/science.283.5400.381 .
PMID
9888852 .
Weng, G; Bhalla, U. S.; Iyengar, R (1999).
"Complexity in biological signaling systems" . Science . 284 (5411): 92–6.
Bibcode :
1999Sci...284...92W .
doi :
10.1126/science.284.5411.92 .
PMC
3773983 .
PMID
10102825 .
Jordan, J. D.; Carey, K. D.; Stork, P. J.; Iyengar, R (1999).
"Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein" . The Journal of Biological Chemistry . 274 (31): 21507–10.
doi :
10.1074/jbc.274.31.21507 .
PMID
10419452 .
Ram, P. T.; Horvath, C. M.; Iyengar, R (2000). "Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein". Science . 287 (5450): 142–4.
Bibcode :
2000Sci...287..142R .
doi :
10.1126/science.287.5450.142 .
PMID
10615050 .
Lipshtat, A; Jayaraman, G; He, J. C.; Iyengar, R (2010).
"Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues" . Proceedings of the National Academy of Sciences . 107 (3): 1247–52.
Bibcode :
2010PNAS..107.1247L .
doi :
10.1073/pnas.0908647107 .
PMC
2824311 .
PMID
20080566 .
Berger, S. I.; Iyengar, R (2011).
"Role of systems pharmacology in understanding drug adverse events" . Wiley Interdisciplinary Reviews: Systems Biology and Medicine . 3 (2): 129–35.
doi :
10.1002/wsbm.114 .
PMC
3057924 .
PMID
20803507 .
Rangamani, P; Fardin, M. A.; Xiong, Y; Lipshtat, A; Rossier, O; Sheetz, M. P.; Iyengar, R (2011).
"Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading" . Biophysical Journal . 100 (4): 845–57.
Bibcode :
2011BpJ...100..845R .
doi :
10.1016/j.bpj.2010.12.3732 .
PMC
3037558 .
PMID
21320428 .
Xiong, Y; Rangamani, P; Fardin, M. A.; Lipshtat, A; Dubin-Thaler, B; Rossier, O; Sheetz, M. P.; Iyengar, R (2010).
"Mechanisms controlling cell size and shape during isotropic cell spreading" . Biophysical Journal . 98 (10): 2136–46.
Bibcode :
2010BpJ....98.2136X .
doi :
10.1016/j.bpj.2010.01.059 .
PMC
2872297 .
PMID
20483321 .
Berger, S. I.; Ma'Ayan, A; Iyengar, R (2010).
"Systems pharmacology of arrhythmias" . Science Signaling . 3 (118): ra30.
doi :
10.1126/scisignal.2000723 .
PMC
3068558 .
PMID
20407125 .
Zorina, Y; Iyengar, R; Bromberg, K. D. (2010).
"Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth" . Journal of Biological Chemistry . 285 (2): 1358–70.
doi :
10.1074/jbc.M109.049841 .
PMC
2801262 .
PMID
19861414 .
Lipshtat, A; Jayaraman, G; He, J. C.; Iyengar, R (2010).
"Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues" . Proceedings of the National Academy of Sciences . 107 (3): 1247–52.
Bibcode :
2010PNAS..107.1247L .
doi :
10.1073/pnas.0908647107 .
PMC
2824311 .
PMID
20080566 .
Berger, S. I.; Iyengar, R (2009).
"Network analyses in systems pharmacology" . Bioinformatics . 25 (19): 2466–72.
doi :
10.1093/bioinformatics/btp465 .
PMC
2752618 .
PMID
19648136 .
Neves, S. R.; Iyengar, R (2009).
"Models of spatially restricted biochemical reaction systems" . Journal of Biological Chemistry . 284 (9): 5445–9.
doi :
10.1074/jbc.R800058200 .
PMC
2645809 .
PMID
18940805 .
Ma'Ayan, A; Cecchi, G. A.; Wagner, J; Rao, A. R.; Iyengar, R; Stolovitzky, G (2008).
"Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks" . Proceedings of the National Academy of Sciences . 105 (49): 19235–40.
Bibcode :
2008PNAS..10519235M .
doi :
10.1073/pnas.0805344105 .
PMC
2614745 .
PMID
19033453 .
Bromberg, K. D.; Ma'Ayan, A; Neves, S. R.; Iyengar, R (2008).
"Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth" . Science . 320 (5878): 903–9.
Bibcode :
2008Sci...320..903B .
doi :
10.1126/science.1152662 .
PMC
2776723 .
PMID
18487186 .
Neves, S. R.; Tsokas, P; Sarkar, A; Grace, E. A.; Rangamani, P; Taubenfeld, S. M.; Alberini, C. M.; Schaff, J. C.; Blitzer, R. D.; Moraru, I. I.; Iyengar, R (2008).
"Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks" . Cell . 133 (4): 666–80.
doi :
10.1016/j.cell.2008.04.025 .
PMC
2728678 .
PMID
18485874 .
Lipshtat, A; Purushothaman, S. P.; Iyengar, R; Ma'Ayan, A (2008).
"Functions of bifans in context of multiple regulatory motifs in signaling networks" . Biophysical Journal . 94 (7): 2566–79.
arXiv :
0711.4937 .
Bibcode :
2008BpJ....94.2566L .
doi :
10.1529/biophysj.107.116673 .
PMC
2267139 .
PMID
18178648 .
Zaidel-Bar, R; Itzkovitz, S; Ma'Ayan, A; Iyengar, R; Geiger, B (2007).
"Functional atlas of the integrin adhesome" . Nature Cell Biology . 9 (8): 858–67.
doi :
10.1038/ncb0807-858 .
PMC
2735470 .
PMID
17671451 .
Ma'Ayan, A; Jenkins, S. L.; Goldfarb, J; Iyengar, R (2007).
"Network analysis of FDA approved drugs and their targets" . Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine . 74 (1): 27–32.
doi :
10.1002/msj.20002 .
PMC
2561141 .
PMID
17516560 .
Eungdamrong, N. J.; Iyengar, R (2007).
"Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi" . Biophysical Journal . 92 (3): 808–15.
Bibcode :
2007BpJ....92..808E .
doi :
10.1529/biophysj.106.093104 .
PMC
1779960 .
PMID
17098795 .
Ma'Ayan, A; Lipshtat, A; Iyengar, R (2006).
"Topology of resultant networks shaped by evolutionary pressure" . Physical Review E . 73 (6 Pt 1): 061912.
Bibcode :
2006PhRvE..73f1912M .
doi :
10.1103/PhysRevE.73.061912 .
PMC
3032447 .
PMID
16906869 .
Ma'Ayan, A; Jenkins, S. L.; Neves, S; Hasseldine, A; Grace, E; Dubin-Thaler, B; Eungdamrong, N. J.; Weng, G; Ram, P. T.; Rice, J. J.; Kershenbaum, A; Stolovitzky, G. A.; Blitzer, R. D.; Iyengar, R (2005).
"Formation of regulatory patterns during signal propagation in a Mammalian cellular network" . Science . 309 (5737): 1078–83.
Bibcode :
2005Sci...309.1078M .
doi :
10.1126/science.1108876 .
PMC
3032439 .
PMID
16099987 .
Ma'Ayan, A; Blitzer, R. D.; Iyengar, R (2005).
"Toward predictive models of mammalian cells" . Annual Review of Biophysics and Biomolecular Structure . 34 : 319–49.
doi :
10.1146/annurev.biophys.34.040204.144415 .
PMC
3035045 .
PMID
15869393 .
Jordan, J. D.; He, J. C.; Eungdamrong, N. J.; Gomes, I; Ali, W; Nguyen, T; Bivona, T. G.; Philips, M. R.; Devi, L. A.; Iyengar, R (2005).
"Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII" . Journal of Biological Chemistry . 280 (12): 11413–21.
doi :
10.1074/jbc.M411521200 .
PMID
15657046 .
Neves, S. R.; Ram, P. T.; Iyengar, R (2002). "G protein pathways". Science . 296 (5573): 1636–9.
Bibcode :
2002Sci...296.1636N .
doi :
10.1126/science.1071550 .
PMID
12040175 .
S2CID
20136388 .
References
External links
International National Academics Other