From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
RAPGEF2 Identifiers
Aliases
RAPGEF2 , CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP, Rap guanine nucleotide exchange factor 2, RAGEFExternal IDs
OMIM :
609530
MGI :
2659071
HomoloGene :
35477
GeneCards :
RAPGEF2
Wikidata
Rap guanine nucleotide exchange factor 2 is a
protein that in humans is encoded by the RAPGEF2
gene .
[5]
[6]
[7]
RAPGEF2 is a
cyclic AMP binding protein.
[8]
[9]
Function
Members of the
RAS subfamily of
GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive
GDP - and active
GTP -bound states.
Guanine nucleotide exchange factors (GEFs) such as RAPGEF2 serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
[6]
Interactions
RAPGEF2 has been shown to
interact with
RAP1A
[6] and
RALGDS .
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000109756 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000062232 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997).
"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 4 (2): 141–50.
doi :
10.1093/dnares/4.2.141 .
PMID
9205841 .
^
a
b
c Rebhun JF, Castro AF, Quilliam LA (November 2000).
"Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction" . J Biol Chem . 275 (45): 34901–8.
doi :
10.1074/jbc.M005327200 .
PMID
10934204 .
^
"Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2" .
^ Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D (May 2000).
"The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP" . Curr. Biol . 10 (9): 555–8.
Bibcode :
2000CBio...10..555P .
doi :
10.1016/S0960-9822(00)00473-5 .
PMID
10801446 .
S2CID
16896523 .
^ Emery AC, Eiden MV, Mustafa T, Eiden LE (2013).
"Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells" . Sci Signal . 6 (281): ra51.
doi :
10.1126/scisignal.2003993 .
PMC
3932028 .
PMID
23800469 .
^ Spaargaren M, Bischoff JR (December 1994).
"Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap" . Proc. Natl. Acad. Sci. U.S.A . 91 (26): 12609–13.
Bibcode :
1994PNAS...9112609S .
doi :
10.1073/pnas.91.26.12609 .
PMC
45488 .
PMID
7809086 .
Further reading
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13.
doi :
10.1006/abio.1996.0138 .
PMID
8619474 .
Yu W, Andersson B, Worley KC, et al. (1997).
"Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8.
doi :
10.1101/gr.7.4.353 .
PMC
139146 .
PMID
9110174 .
Ohtsuka T, Hata Y, Ide N, et al. (1999). "nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)". Biochem. Biophys. Res. Commun . 265 (1): 38–44.
doi :
10.1006/bbrc.1999.1619 .
PMID
10548487 .
Liao Y, Kariya K, Hu CD, et al. (2000).
"RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans" . J. Biol. Chem . 274 (53): 37815–20.
doi :
10.1074/jbc.274.53.37815 .
PMID
10608844 .
de Rooij J, Boenink NM, van Triest M, et al. (2000).
"PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2" . J. Biol. Chem . 274 (53): 38125–30.
doi :
10.1074/jbc.274.53.38125 .
PMID
10608883 .
Chikumi H, Fukuhara S, Gutkind JS (2002).
"Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase" . J. Biol. Chem . 277 (14): 12463–73.
doi :
10.1074/jbc.M108504200 .
PMID
11799111 .
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis . 8 : 171–84.
PMID
12107413 .
Aurandt J, Vikis HG, Gutkind JS, et al. (2002).
"The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG" . Proc. Natl. Acad. Sci. U.S.A . 99 (19): 12085–90.
Bibcode :
2002PNAS...9912085A .
doi :
10.1073/pnas.142433199 .
PMC
129402 .
PMID
12196628 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Hisata S, Sakisaka T, Baba T, et al. (2007).
"Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth" . J. Cell Biol . 178 (5): 843–60.
doi :
10.1083/jcb.200610073 .
PMC
2064548 .
PMID
17724123 .