From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Rab GTPase-binding effector protein 1 is an
enzyme that in humans is encoded by the RABEP1
gene .
[5]
[6] It belongs to
rabaptin protein family.
Interactions
RABEP1 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000029725 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020817 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Stenmark H, Vitale G, Ullrich O, Zerial M (Nov 1995).
"Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion" . Cell . 83 (3): 423–32.
doi :
10.1016/0092-8674(95)90120-5 .
PMID
8521472 .
^
"Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1" .
^
a
b
c Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003).
"Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . The EMBO Journal . 22 (1): 78–88.
doi :
10.1093/emboj/cdg015 .
PMC
140067 .
PMID
12505986 .
^ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology . 9 (7): 527–31.
doi :
10.1038/nsb808 .
PMID
12042876 .
S2CID
42630285 .
^
a
b Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998).
"Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5" . The EMBO Journal . 17 (7): 1941–51.
doi :
10.1093/emboj/17.7.1941 .
PMC
1170540 .
PMID
9524117 .
^ Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997).
"The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis" . The Journal of Biological Chemistry . 272 (10): 6097–100.
doi :
10.1074/jbc.272.10.6097 .
hdl :
20.500.12613/9244 .
PMID
9045618 .
^ Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001).
"Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER" . FEBS Letters . 508 (2): 201–9.
doi :
10.1016/s0014-5793(01)02993-3 .
PMID
11718716 .
S2CID
21545088 .
Further reading
Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997).
"The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis" . The Journal of Biological Chemistry . 272 (10): 6097–100.
doi :
10.1074/jbc.272.10.6097 .
hdl :
20.500.12613/9244 .
PMID
9045618 .
Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998).
"Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5" . The EMBO Journal . 17 (7): 1941–51.
doi :
10.1093/emboj/17.7.1941 .
PMC
1170540 .
PMID
9524117 .
Neve RL, Coopersmith R, McPhie DL, Santeufemio C, Pratt KG, Murphy CJ, Lynn SD (Oct 1998).
"The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis" . The Journal of Neuroscience . 18 (19): 7757–67.
doi :
10.1523/JNEUROSCI.18-19-07757.1998 .
PMC
6793001 .
PMID
9742146 .
Swanton E, Bishop N, Woodman P (Dec 1999).
"Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis" . The Journal of Biological Chemistry . 274 (53): 37583–90.
doi :
10.1074/jbc.274.53.37583 .
PMID
10608812 .
Nagelkerken B, Van Anken E, Van Raak M, Gerez L, Mohrmann K, Van Uden N, Holthuizen J, Pelkmans L, Van Der Sluijs P (Mar 2000).
"Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles" . The Biochemical Journal . 346 (3): 593–601.
doi :
10.1042/0264-6021:3460593 .
PMC
1220890 .
PMID
10698684 .
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (Apr 2000).
"A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome" . The Journal of Cell Biology . 149 (1): 67–80.
doi :
10.1083/jcb.149.1.67 .
PMC
2175106 .
PMID
10747088 .
Korobko IV, Korobko EV, Kiselev SL (Nov 2000). "The MAK-V protein kinase regulates endocytosis in mouse". Molecular & General Genetics . 264 (4): 411–8.
doi :
10.1007/s004380000293 .
PMID
11129044 .
S2CID
21231710 .
Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S (Jun 2001). "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor". Science . 292 (5522): 1716–8.
Bibcode :
2001Sci...292.1716Z .
doi :
10.1126/science.1060896 .
PMID
11387476 .
S2CID
9453730 .
Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001).
"Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER" . FEBS Letters . 508 (2): 201–9.
doi :
10.1016/S0014-5793(01)02993-3 .
PMID
11718716 .
S2CID
21545088 .
de Renzis S, Sönnichsen B, Zerial M (Feb 2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nature Cell Biology . 4 (2): 124–33.
doi :
10.1038/ncb744 .
PMID
11788822 .
S2CID
6596498 .
Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003).
"Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . The EMBO Journal . 22 (1): 78–88.
doi :
10.1093/emboj/cdg015 .
PMC
140067 .
PMID
12505986 .
Mattera R, Puertollano R, Smith WJ, Bonifacino JS (Jul 2004).
"The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites" . The Journal of Biological Chemistry . 279 (30): 31409–18.
doi :
10.1074/jbc.M402183200 .
PMID
15143060 .
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Current Biology . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .