From Wikipedia, the free encyclopedia
Medical compound
Anthramycin contains pyrrolobenzodiazepine core
Pyrrolobenzodiazepines, (PBD) are a class of compound that may have
antibiotic or anti-tumor properties.
[1]
Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in
antibody-drug conjugates , for example in
loncastuximab tesirine .
History
Anthramycin , the first PBD monomer, was first synthesized in the 1960s.
[2]
References
^ Hartley JA (June 2011). "The development of pyrrolobenzodiazepines as antitumour agents". Expert Opinion on Investigational Drugs . 20 (6): 733–44.
doi :
10.1517/13543784.2011.573477 .
PMID
21457108 .
S2CID
26275418 .
^ From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs) Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488.
Published online 2016 Nov 15. doi: 10.1002/anie.201510610