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Chemical compound
Promestriene
Trade names Colpotrofin, Colpotrophine, Delipoderm Other names Estradiol 3-propyl 17β-methyl diether; 17β-Methoxy-3-propoxyestra-1,3,5(10)-triene
Routes of administration
Topical
Drug class
Estrogen ;
Estrogen ester
ATC code
(8R ,9S ,13S ,14S )-17-methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a ]phenanthrene
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
ECHA InfoCard
100.049.401
Formula C 22 H 32 O 2
Molar mass 328.496 g·mol−1 3D model (
JSmol )
CCCOc1ccc2c(c1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4OC)C
InChI=1S/C22H32O2/c1-4-13-24-16-6-8-17-15(14-16)5-7-19-18(17)11-12-22(2)20(19)9-10-21(22)23-3/h6,8,14,18-21H,4-5,7,9-13H2,1-3H3/t18-,19-,20+,21?,22+/m1/s1
N Key:IUWKNLFTJBHTSD-QIKJAYGVSA-N
N
(verify)
Promestriene (
INN Tooltip International Nonproprietary Name ) (brand names Colpotrofin , Colpotrophine , Delipoderm ), also known as estradiol 3-propyl 17β-methyl diether , is a
synthetic
estrogen which is used
topically in a 1%
cream formulation for the treatment of
vaginal atrophy in women.
[1]
[2]
[3]
[4]
[5] It is the 3-
propyl and 17β-
methyl
diether of
estradiol and does not appear to convert into estradiol in the body.
[1]
[6] Promestriene is minimally
absorbed and appears to have negligible systemic estrogenic effect.
[1] The drug has been described as a
tropic agent and
antiseborrheic .
[2] It has not been found to be effective in the treatment of
pattern hair loss or other conditions of
cutaneous
androgenization .
[7]
[8] Promestriene was first introduced in
France in 1974 and has been marketed in 34 countries worldwide.
[1] It has been used in millions of women.
[1]
See also
References
^
a
b
c
d
e Del Pup L, Di Francia R, Cavaliere C, Facchini G, Giorda G, De Paoli P, Berretta M (November 2013). "Promestriene, a specific topic estrogen. Review of 40 years of vaginal atrophy treatment: is it safe even in cancer patients?". Anti-Cancer Drugs . 24 (10): 989–998.
doi :
10.1097/CAD.0b013e328365288e .
PMID
24080714 .
S2CID
3458356 .
^
a
b Ganellin CR, Triggle DJ (21 November 1996).
Dictionary of Pharmacological Agents . CRC Press. pp. 1671–.
ISBN
978-0-412-46630-4 .
^
Index Nominum 2000: International Drug Directory . Taylor & Francis. January 2000. pp. 1248, 1266, 1318, 1557.
ISBN
978-3-88763-075-1 .
^ William Andrew Publishing (22 October 2013).
Pharmaceutical Manufacturing Encyclopedia, 3rd Edition . Elsevier. pp. 270–271.
ISBN
978-0-8155-1856-3 .
^ Muller (19 June 1998).
European Drug Index: European Drug Registrations, Fourth Edition . CRC Press. pp. 289, 33 2.
ISBN
978-3-7692-2114-5 .
^ Santos I, Clissold S (September 2010). "Urogenital disorders associated with oestrogen deficiency: the role of promestriene as topical oestrogen therapy". Gynecological Endocrinology . 26 (9): 644–651.
doi :
10.3109/09513591003767948 .
PMID
20374067 .
S2CID
243338 .
^ Orfanos CE, Montagna W, Stüttgen G (6 December 2012).
Hair Research: Status and Future Aspects; Proceedings of the First International Congress on Hair Research, Hamburg, March 13th–16, 1979 . Springer Science & Business Media. pp. 553–.
ISBN
978-3-642-81650-5 .
^ Beylot C (1 October 1998).
"Menopause, Skin, and Cosmetology" . In Baran R, Maibach HI (eds.). Textbook of Cosmetic Dermatology . CRC Press. pp. 493–.
ISBN
978-1-85317-478-0 .
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zearalenone ,
zeranol (α-zearalanol) ,
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