Skyline Drive is a 105-mile (169 km) road that runs the entire length of the National Park Service's Shenandoah National Park in the Blue Ridge Mountains of Virginia, generally along the ridge of the mountains. The drive's northern terminus is at an intersection with U.S. Route 340 (US 340) near Front Royal, and the southern terminus is at an interchange with US 250 in Rockfish Gap, where the road continues south as the Blue Ridge Parkway.

A park entrance fee is charged at the four access points to the drive. Skyline Drive is a two-lane road that has 75 overlooks providing views of the Shenandoah Valley to the west and the Piedmont to the east. The drive provides access to numerous trails, including the Appalachian Trail, and it is also used for biking and horseback riding. Skyline Drive is the main road through Shenandoah National Park and has access to campgrounds, visitor centers, and resorts such as Skyland Resort and Big Meadows. The scenic drive is particularly popular in the fall for leaf peeping when the leaves are changing colors. Skyline Drive is designated a National Scenic Byway and a National Historic Landmark and is listed on the National Register of Historic Places.

Plans for the road date back to 1924 when a national park was planned in the Blue Ridge Mountains of Virginia and the main feature was to be a "sky-line drive" providing views of the surrounding land. Groundbreaking for Skyline Drive took place in 1931. The first section, which originally was to run from Rapidan Camp to Skyland, was extended between Swift Run Gap and Thornton Gap and opened in 1934. The Civilian Conservation Corps played a large part in constructing Skyline Drive. Improvements have been made to the roadway since it was built. Skyline Drive was added to the National Register of Historic Places in 1997, became a National Scenic Byway in 2005, and was designated a National Historic Landmark in 2008.