From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
"Noxa" redirects here. For the Indonesian grindcore band, see
Noxa (band) .
Phorbol-12-myristate-13-acetate-induced protein 1 is a
protein that in humans is encoded by the PMAIP1
gene , and is also known as Noxa.
[3]
[4]
[5]
Noxa (Latin for damage ) is a pro-
apoptotic member of the
Bcl-2 protein family.
[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor
p53 , and Noxa has been shown to be involved in p53-mediated apoptosis.
Interactions
Noxa has been shown to
interact with:
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000141682 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990).
"Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line" . J Virol . 64 (10): 4632–9.
doi :
10.1128/JVI.64.10.4632-4639.1990 .
PMC
247947 .
PMID
2398525 .
^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene . 22 (30): 4675–8.
doi :
10.1038/sj.onc.1206655 .
PMID
12879012 .
^
"Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1" .
^ Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science . 288 (5468): 1053–1058.
Bibcode :
2000Sci...288.1053O .
doi :
10.1126/science.288.5468.1053 .
PMID
10807576 .
^
a
b
c Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005).
"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function" . Mol. Cell . 17 (3): 393–403.
doi :
10.1016/j.molcel.2004.12.030 .
PMID
15694340 .
^
a
b Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science . 288 (5468): 1053–8.
Bibcode :
2000Sci...288.1053O .
doi :
10.1126/science.288.5468.1053 .
PMID
10807576 .
^ Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (June 2005).
"Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins" . Genes Dev . 19 (11): 1294–305.
doi :
10.1101/gad.1304105 .
PMC
1142553 .
PMID
15901672 .
^ Heckmeier PJ, Ruf J, Janković BG, Hamm P (7 March 2023).
"MCL-1 promiscuity and the structural resilience of its binding partners" . The Journal of Chemical Physics . 158 (9).
arXiv :
2211.08934 .
Bibcode :
2023JChPh.158i5101H .
doi :
10.1063/5.0137239 .
PMID
36889945 .
Further reading
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science . 288 (5468): 1053–8.
Bibcode :
2000Sci...288.1053O .
doi :
10.1126/science.288.5468.1053 .
PMID
10807576 .
Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH (2004).
"The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death" . J. Biol. Chem . 278 (48): 48292–9.
doi :
10.1074/jbc.M308785200 .
PMID
14500711 .
Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH (2004).
"BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha" . J. Exp. Med . 199 (1): 113–24.
doi :
10.1084/jem.20030613 .
PMC
1887730 .
PMID
14699081 .
Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI (2004).
"BOK and NOXA are essential mediators of p53-dependent apoptosis" . J. Biol. Chem . 279 (27): 28367–74.
doi :
10.1074/jbc.M313526200 .
PMID
15102863 .
Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L, Nickoloff BJ (2005).
"p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas" . Mol. Cancer Ther . 3 (8): 895–902.
doi :
10.1158/1535-7163.895.3.8 .
PMID
15299072 .
S2CID
34940117 .
Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gäken J, Tavassoli M (2005).
"E1A activates transcription of p73 and Noxa to induce apoptosis" (PDF) . J. Biol. Chem . 280 (7): 5945–59.
doi :
10.1074/jbc.M406661200 .
PMID
15572378 .
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005).
"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function" . Mol. Cell . 17 (3): 393–403.
doi :
10.1016/j.molcel.2004.12.030 .
PMID
15694340 .
Sun Y, Leaman DW (2005).
"Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection" . J. Biol. Chem . 280 (16): 15561–8.
doi :
10.1074/jbc.M412630200 .
PMID
15705586 .
Ceballos E, Muñoz-Alonso MJ, Berwanger B, Acosta JC, Hernández R, Krause M, Hartmann O, Eilers M, León J (2005). "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes". Oncogene . 24 (28): 4559–71.
doi :
10.1038/sj.onc.1208652 .
PMID
15856024 .
S2CID
21190604 .
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (2005).
"Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins" . Genes Dev . 19 (11): 1294–305.
doi :
10.1101/gad.1304105 .
PMC
1142553 .
PMID
15901672 .
Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E (2006).
"The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells" . Immunity . 24 (6): 703–16.
doi :
10.1016/j.immuni.2006.03.018 .
PMID
16782027 .
Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ (2007).
"FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells" . Cell Death Differ . 14 (3): 534–47.
doi :
10.1038/sj.cdd.4402017 .
PMID
16888645 .
Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (2006).
"Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa" . J. Biol. Chem . 281 (42): 31440–7.
doi :
10.1074/jbc.M604356200 .
PMID
16928686 .
Smit LA, Hallaert DY, Spijker R, de Goeij B, Jaspers A, Kater AP, van Oers MH, van Noesel CJ, Eldering E (2007). "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity". Blood . 109 (4): 1660–8.
doi :
10.1182/blood-2006-05-021683 .
PMID
17038534 .
S2CID
16995479 .
Armstrong JL, Veal GJ, Redfern CP, Lovat PE (2007). "Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours". Apoptosis . 12 (3): 613–22.
doi :
10.1007/s10495-006-0020-1 .
PMID
17216584 .
S2CID
41674871 .
Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, et al. (2022).
"NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer" . Proc Natl Acad Sci USA . 119 (9).
Bibcode :
2022PNAS..11905691D .
doi :
10.1073/pnas.2105691119 .
PMC
8892327 .
PMID
35197278 .
External links