Paul B. Sigler | |
|---|---|
| Born | February 19, 1934
[1] |
| Died | January 11, 2000 (aged 65)
[1] |
| Monuments |
|
| Nationality | American |
| Occupation | Professor [3] |
| Spouse | Althea Jo Martin Sigler [2] |
| Children | 5 children [2] |
| Alma mater |
Princeton University Columbia University (MD) Cambridge University (PhD) [2] |
| Known for |
Phospholipase A2 trp repressor [1] |
| Awards |
National Academy of Sciences
[2] HHMI Investigator [4] Guggenheim Fellow [2] Helen Hay Whitney Fellow [5] |
| Scientific career | |
| Fields |
Biophysics Biochemistry [3] |
| Institutions |
Yale University
[3] University of Chicago MRC-LMB NIH [2] |
| Doctoral advisors | David M. Blow [6] |
| Website |
www |
Paul B. Sigler (February 19, 1934 – January 11, 2000 [7] [1]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University. [3] [8] Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim [2] and Helen Hay Whitney Fellowships. [5] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others. [1]
Biography
Prior to coming to Yale, he was a professor at the University of Chicago. [2] He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955. [2] After briefly practicing medicine and working as a researcher for the NIH, [5] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology [2] working under David M. Blow [6] before moving to the University of Chicago. [2]
Memorials
A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. [9] Yale also has sponsored Paul Sigler memorial symposia in the past. [10] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006. [11]
Death
Paul Sigler died on January 11, 2000, at New Haven, Connecticut, US, about a month before his 66th birthday.[ citation needed]
Selected publications
- Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311–9. Bibcode: 1996Natur.379..311L. doi: 10.1038/379311a0. PMID 8552184. S2CID 4350943.
- Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497–505. Bibcode: 1991Natur.352..497L. doi: 10.1038/352497a0. PMID 1865905. S2CID 1919276.
- Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578–86. Bibcode: 1994Natur.371..578B. doi: 10.1038/371578a0. PMID 7935790. S2CID 4341993.
- Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "Crystal structure of a yeast TBP/TATA-box complex". Nature. 365 (6446): 512–20. Bibcode: 1993Natur.365..512K. doi: 10.1038/365512a0. PMID 8413604. S2CID 4336203.
- Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911–6. Bibcode: 1989Sci...246..911V. doi: 10.1126/science.2683088. PMID 2683088.
- Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. Bibcode: 1988Natur.335..321O. doi: 10.1038/335321a0. PMID 3419502. S2CID 9358980.
See also
References
- ^ a b c d e "(IUCr) Paul B. Sigler (1934-2000)".
- ^ a b c d e f g h i j k l m Saxon, Wolfgang (15 January 2000). "New York Times Obit". The New York Times.
- ^ a b c d "Yale University Press Release". 23 October 1998.
- ^ "Paul B. Sigler, MD, PhD - HHMI.org". HHMI.org.
- ^ a b c "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
- ^ a b "Blow on AcademicTree.org".
- ^ National Academy of Sciences
- ^ "Official Site".
- ^ Paul Sigler Memorial
- ^ "Paul Sigler Symposium".
- ^ "Helen Hay Whitney Foundation - Announcement".
Further reading
- Saxon, Wolfgang (15 January 2000). "New York Times Obit". The New York Times.
- "Yale obit".
- "(IUCr) Paul B. Sigler (1934-2000)".
- "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
- Brian W. Matthews (2000). "Obituary: Paul Sigler (1934–2000)". Nature. 403 (6772): 848. Bibcode: 2000Natur.403..848M. doi: 10.1038/35002722. PMID 10706270. S2CID 205004640.
- Henderson, Richard (2000). "Paul Sigler: A structural biologist with passion". Nature Structural Biology. 7 (4): 271–272. doi: 10.1038/74024. S2CID 34789342.
- Jeruzalmi, David; Kuriyan, John; Doudna, Jennifer (2000). "Paul Sigler (1934–2000)". Trends in Biochemical Sciences. 25 (5): 221–2. doi: 10.1016/S0968-0004(00)01587-5. PMID 10782089.
- Horwich, A; Joachimiak, A (2000). "Paul Sigler (1934–2000)". Protein Science. 9 (4): 827–828. PMC 2144625.
- Perutz, Max (2000). "Paul Sigler (1934–2000)". Cell. 101 (1): 23–4. doi: 10.1016/S0092-8674(02)71111-2. PMID 10778852.
- Davies, David R (2000). "Obituary: Paul Sigler". Structure. 8 (3): R67–8. doi: 10.1016/S0969-2126(00)00113-1. PMID 10745016.
External links
| International | |
|---|---|
| National | |
- Princeton University alumni
- American biophysicists
- 20th-century American biochemists
- Yale University faculty
- University of Chicago faculty
- Yale Department of Molecular Biophysics & Biochemistry faculty
- Scientists from New Haven, Connecticut
- Scientists from Chicago
- Scientists from New York City
- Scientists from Cambridge
- Scientists from Princeton, New Jersey
- Scientists from Washington, D.C.
- People from Richmond, Virginia
- Members of the United States National Academy of Sciences
- Howard Hughes Medical Investigators
- 1934 births
- 2000 deaths
- Columbia University Vagelos College of Physicians and Surgeons alumni
- Alumni of the University of Cambridge
- Physicians from New Haven, Connecticut
- Scientists from Virginia