In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted allograft sensitize the recipient's alloreactive T-lymphocytes, causing transplant rejection. [1]
The concept was first proposed by George Davis Snell [2] and the term coined in 1968 when Elkins and Guttmann showed that leukocytes present in a donor graft initiate an immune response in the recipient of a transplant. [3]
See also
References
- ^ Thaunat, Olivier; Morelon, Emmanuel (2007). "Modulation of Immunogenicity". In Lanzetta, Marco; Dubernard, Jean-Michel (eds.). Hand transplantation. Springer. pp. 210–1. ISBN 978-88-470-0374-3.
- ^ Snell, George D. (1957). "The homograft reaction". Annual Review of Microbiology. 11: 439–58. doi: 10.1146/annurev.mi.11.100157.002255. PMID 13470828.
- ^ Elkins, William L.; Guttmann, Ronald D. (1968). "Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes". Science. 159 (3820): 1250–1. Bibcode: 1968Sci...159.1250E. doi: 10.1126/science.159.3820.1250. PMID 4886081. S2CID 84424102.
Further reading
- Audet, Maxime; Panaro, Fabrizio; Piardi, Tullio; Huang, Ping; Cag, Murat; Cinqualbre, Jacques; Wolf, Philippe (2008). "Passenger Lymphocyte Syndrome and Liver Transplantation". Clinical and Developmental Immunology. 2008: 715769. doi: 10.1155/2008/715769. PMC 2652582. PMID 19277202.
- Demetris, AJ; Murase, N; Rao, AS; Fung, JJ; Starzl, TE (1995). "The dichotomous functions of passenger leukocytes in solid-organ transplantation". Advances in Nephrology from the Necker Hospital. 24: 341–54. PMC 2987699. PMID 7572418.
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