From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cytosolic
phospholipase A2 gamma is an
enzyme that in
humans is encoded by the PLA2G4C
gene .
[5]
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000105499 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000033847 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL (Sep 1998).
"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2" . J Biol Chem . 273 (34): 21926–32.
doi :
10.1074/jbc.273.34.21926 .
PMID
9705332 .
^
"Entrez Gene: PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)" .
Further reading
Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology . 19 (4–5): 683–8.
PMID
9745929 .
Wu T, Angus CW, Yao XL, Logun C, Shelhamer JH (1997).
"P11, a unique member of the S100 family of calcium-binding proteins, interacts with and inhibits the activity of the 85-kDa cytosolic phospholipase A2" . J. Biol. Chem . 272 (27): 17145–53.
doi :
10.1074/jbc.272.27.17145 .
PMID
9202034 .
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, Nguyen HT, Yaba P, Delicat A, Georges AJ, Russo-Marie F (1997).
"HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes" . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol . 16 (1): 1–9.
doi :
10.1097/00042560-199709010-00001 .
PMID
9377118 .
Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999).
"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2" . J. Biol. Chem . 274 (13): 8823–31.
doi :
10.1074/jbc.274.13.8823 .
PMID
10085124 .
Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics . 64 (1): 44–50.
doi :
10.1006/geno.1999.6101 .
PMID
10708517 .
Hartmann C, Johnk L, Sasaki H, Jenkins RB, Louis DN (2002).
"Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas" . Brain Pathol . 12 (2): 178–82.
doi :
10.1111/j.1750-3639.2002.tb00432.x .
PMC
8095768 .
PMID
11958371 .
S2CID
2579203 .
Stewart A, Ghosh M, Spencer DM, Leslie CC (2002).
"Enzymatic properties of human cytosolic phospholipase A(2)gamma" . J. Biol. Chem . 277 (33): 29526–36.
doi :
10.1074/jbc.M204856200 .
PMID
12039969 .
Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res . 22 (9): 947–55.
doi :
10.1089/10799900260286650 .
PMID
12396716 .
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Asai K, Hirabayashi T, Houjou T, Uozumi N, Taguchi R, Shimizu T (2003).
"Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress" . J. Biol. Chem . 278 (10): 8809–14.
doi :
10.1074/jbc.M212117200 .
PMID
12502717 .
Jenkins CM, Han X, Yang J, Mancuso DJ, Sims HF, Muslin AJ, Gross RW (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry . 42 (40): 11798–807.
doi :
10.1021/bi034611q .
PMID
14529291 .
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Dong M, Johnson M, Rezaie A, Ilsley JN, Nakanishi M, Sanders MM, Forouhar F, Levine J, Montrose DC (2005).
"Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis" . Clin. Cancer Res . 11 (6): 2265–71.
doi :
10.1158/1078-0432.CCR-04-1079 .
PMID
15788676 .
Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW (2005).
"The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling" . J. Biol. Chem . 280 (29): 26669–79.
doi :
10.1074/jbc.M502358200 .
PMID
15908428 .
Yamashita A, Kamata R, Kawagishi N, Nakanishi H, Suzuki H, Sugiura T, Waku K (2005).
"Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)" . J. Biochem . 137 (5): 557–67.
doi :
10.1093/jb/mvi067 .
PMID
15944408 .
Zhao X, Wang D, Zhao Z, Xiao Y, Sengupta S, Xiao Y, Zhang R, Lauber K, Wesselborg S (2006).
"Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells" . J. Biol. Chem . 281 (39): 29357–68.
doi :
10.1074/jbc.M513105200 .
PMID
16882668 .