From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an
enzyme which in humans is encoded by the PHLPP
gene.
[5]
See also
References
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003).
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106.
doi:
10.1093/dnares/9.3.99.
PMID
12168954.
- Nagase T, Ishikawa K, Miyajima N, et al. (1998).
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9.
doi:
10.1093/dnares/5.1.31.
PMID
9628581.
- Shimizu K, Okada M, Takano A, Nagai K (2000).
"SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9.
doi:
10.1016/S0014-5793(99)01190-4.
PMID
10570941.
S2CID
38044717.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Gao T, Furnari F, Newton AC (2005).
"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24.
doi:
10.1016/j.molcel.2005.03.008.
PMID
15808505.
- Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005).
"Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50.
doi:
10.1074/mcp.M500089-MCP200.
PMID
15951569.
- Nusbaum C, Zody MC, Borowsky ML, et al. (2005).
"DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5.
Bibcode:
2005Natur.437..551N.
doi:
10.1038/nature03983.
PMID
16177791.
- Brognard J, Sierecki E, Gao T, Newton AC (2007).
"PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31.
doi:
10.1016/j.molcel.2007.02.017.
PMID
17386267.