From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Procollagen C-endopeptidase enhancer 1 is an
enzyme that in humans is encoded by the PCOLCE
gene .
[5]
[6]
[7]
Fibrillar collagen types I-III are synthesized as precursor molecules known as
procollagens . These precursors contain amino- and carboxyl-terminal
peptide extensions known as N- and C-
propeptides , respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured
fibrils . This gene encodes a
glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens activity.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000106333 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000029718 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). "Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics . 31 (2): 253–256.
doi :
10.1006/geno.1996.0043 .
PMID
8824813 .
^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998).
"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes" . Genome Res . 8 (10): 1060–1073.
doi :
10.1101/gr.8.10.1060 .
PMC
310788 .
PMID
9799793 .
^
a
b
"Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer" .
Further reading
Takahara K, Kessler E, Biniaminov L, et al. (1994).
"Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE)" . J. Biol. Chem . 269 (42): 26280–26285.
doi :
10.1016/S0021-9258(18)47191-8 .
PMID
7523404 .
Scott IC, Clark TG, Takahara K, et al. (1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein". Genomics . 55 (2): 229–234.
doi :
10.1006/geno.1998.5663 .
PMID
9933570 .
Mott JD, Thomas CL, Rosenbach MT, et al. (2000).
"Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor" . J. Biol. Chem . 275 (2): 1384–1390.
doi :
10.1074/jbc.275.2.1384 .
PMID
10625689 .
Ricard-Blum S, Bernocco S, Font B, et al. (2002).
"Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1" . J. Biol. Chem . 277 (37): 33864–33869.
doi :
10.1074/jbc.M205018200 .
PMID
12105202 .
Ligon AH, Scott IC, Takahara K, et al. (2002). "PCOLCE deletion and expression analyses in uterine leiomyomata". Cancer Genet. Cytogenet . 137 (2): 133–137.
doi :
10.1016/S0165-4608(02)00547-2 .
PMID
12393284 .
Steiglitz BM, Keene DR, Greenspan DS (2003).
"PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1" . J. Biol. Chem . 277 (51): 49820–49830.
doi :
10.1074/jbc.M209891200 .
PMID
12393877 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Bernocco S, Steiglitz BM, Svergun DI, et al. (2003).
"Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein" . J. Biol. Chem . 278 (9): 7199–7205.
doi :
10.1074/jbc.M210857200 .
PMID
12486138 .
Liepinsh E, Banyai L, Pintacuda G, et al. (2003).
"NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding" . J. Biol. Chem . 278 (28): 25982–25989.
doi :
10.1074/jbc.M302734200 .
PMID
12670942 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Petropoulou V, Garrigue-Antar L, Kadler KE (2005).
"Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)" . J. Biol. Chem . 280 (24): 22616–22623.
doi :
10.1074/jbc.M413468200 .
PMID
15817489 .
Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006).
"Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains" . J. Biol. Chem . 281 (16): 10786–10798.
doi :
10.1074/jbc.M511111200 .
PMID
16507574 .
Blanc G, Font B, Eichenberger D, et al. (2007).
"Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity" . J. Biol. Chem . 282 (23): 16924–16933.
doi :
10.1074/jbc.M701610200 .
PMID
17446170 .