Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a
protein that in humans is encoded by the PA2G4gene.[5]
Function
This gene encodes an
RNA-binding protein that is involved in growth regulation. This protein is present in pre-
ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the
ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional
corepressor of
androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with
histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer,[6] but increased in Acute Myelogneous Leukemia.[7] Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS (November 1997). "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4". Cytogenetics and Cell Genetics. 78 (1): 31–5.
doi:
10.1159/000134621.
PMID9345902.
Radomski N, Jost E (October 1995). "Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle". Experimental Cell Research. 220 (2): 434–45.
doi:
10.1006/excr.1995.1335.
PMID7556453.
Xia X, Lessor TJ, Zhang Y, Woodford N, Hamburger AW (November 2001). "Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein". Biochemical and Biophysical Research Communications. 289 (1): 240–4.
doi:
10.1006/bbrc.2001.5942.
PMID11708806.