From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Phosphatidylinositol 3-kinase regulatory subunit beta is an
enzyme that in humans is encoded by the PIK3R2
gene .
[4]
[5]
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.
[6]
Interactions
PIK3R2 has been shown to
interact with:
Clinical relevance
PIK3R2 mutations were recently shown to be associated with
polymicrogyria .
[12]
References
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031834 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene . 7 (4): 789–793.
PMID
1314371 .
^
"Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)" .
^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022).
"Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning" . BioData Mining . 15 (1): 28.
doi :
10.1186/s13040-022-00312-y .
eISSN
1756-0381 .
PMC
9632055 .
PMID
36329531 .
^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997).
"Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)" . The Journal of Biological Chemistry . 272 (15): 10248–10253.
doi :
10.1074/jbc.272.15.10248 .
PMID
9092574 .
^ Lin H, Martelli MP, Bierer BE (January 2001).
"The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation" . International Immunology . 13 (1): 13–22.
doi :
10.1093/intimm/13.1.13 .
PMID
11133830 .
^ Hartley D, Meisner H, Corvera S (August 1995).
"Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl" . The Journal of Biological Chemistry . 270 (31): 18260–18263.
doi :
10.1074/jbc.270.31.18260 .
PMID
7629144 .
^
a
b
c
d Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992).
"Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system" . The Biochemical Journal . 288 ( Pt 2) (2): 395–405.
doi :
10.1042/bj2880395 .
PMC
1132024 .
PMID
1334406 .
^ Vanhaesebroeck B,
Welham MJ , Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997).
"P110delta, a novel phosphoinositide 3-kinase in leukocytes" . Proceedings of the National Academy of Sciences of the United States of America . 94 (9): 4330–4335.
Bibcode :
1997PNAS...94.4330V .
doi :
10.1073/pnas.94.9.4330 .
PMC
20722 .
PMID
9113989 .
^ Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015).
"Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study" . The Lancet. Neurology . 14 (12): 1182–1195.
doi :
10.1016/S1474-4422(15)00278-1 .
PMC
4672724 .
PMID
26520804 .
Further reading
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003).
"Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways" . Journal of Leukocyte Biology . 74 (5): 676–682.
doi :
10.1189/jlb.0503206 .
PMID
12960231 .
S2CID
11362623 .
Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992).
"Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system" . The Biochemical Journal . 288 ( Pt 2) (2): 395–405.
doi :
10.1042/bj2880395 .
PMC
1132024 .
PMID
1334406 .
Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990).
"Purification and characterization of phosphoinositide 3-kinase from rat liver" . The Journal of Biological Chemistry . 265 (32): 19704–19711.
doi :
10.1016/S0021-9258(17)45429-9 .
PMID
2174051 .
Truitt KE, Hicks CM, Imboden JB (March 1994).
"Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells" . The Journal of Experimental Medicine . 179 (3): 1071–1076.
doi :
10.1084/jem.179.3.1071 .
PMC
2191424 .
PMID
7509360 .
Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry . 34 (17): 5971–5979.
doi :
10.1021/bi00017a026 .
PMID
7537096 .
Craparo A, O'Neill TJ, Gustafson TA (June 1995).
"Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor" . The Journal of Biological Chemistry . 270 (26): 15639–15643.
doi :
10.1074/jbc.270.26.15639 .
PMID
7541045 .
He W, O'Neill TJ, Gustafson TA (October 1995).
"Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains" . The Journal of Biological Chemistry . 270 (40): 23258–23262.
doi :
10.1074/jbc.270.40.23258 .
PMID
7559478 .
Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995).
"Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin" . The Journal of Biological Chemistry . 270 (43): 25985–25991.
doi :
10.1074/jbc.270.43.25985 .
PMID
7592789 .
Hartley D, Meisner H, Corvera S (August 1995).
"Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl" . The Journal of Biological Chemistry . 270 (31): 18260–18263.
doi :
10.1074/jbc.270.31.18260 .
PMID
7629144 .
Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994).
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity" . The Journal of Biological Chemistry . 269 (48): 30154–30157.
doi :
10.1016/S0021-9258(18)43790-8 .
PMID
7982920 .
August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology . 6 (5): 769–774.
doi :
10.1093/intimm/6.5.769 .
PMID
8080844 .
Fukazawa T, Miyake S, Band V, Band H (June 1996).
"Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins" . The Journal of Biological Chemistry . 271 (24): 14554–14559.
doi :
10.1074/jbc.271.24.14554 .
PMID
8662998 .
Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996).
"Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells" . The Journal of Biological Chemistry . 271 (38): 22961–22964.
doi :
10.1074/jbc.271.38.22961 .
PMID
8798481 .
Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997).
"Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)" . The Journal of Biological Chemistry . 272 (15): 10248–10253.
doi :
10.1074/jbc.272.15.10248 .
PMID
9092574 .
Vanhaesebroeck B,
Welham MJ , Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997).
"P110delta, a novel phosphoinositide 3-kinase in leukocytes" . Proceedings of the National Academy of Sciences of the United States of America . 94 (9): 4330–4335.
Bibcode :
1997PNAS...94.4330V .
doi :
10.1073/pnas.94.9.4330 .
PMC
20722 .
PMID
9113989 .
Briand G, Barbeau B, Tremblay M (February 1997).
"Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase" . Virology . 228 (2): 171–179.
doi :
10.1006/viro.1996.8399 .
PMID
9123823 .
Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997).
"Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site" . Oncogene . 14 (22): 2619–2631.
doi :
10.1038/sj.onc.1201123 .
PMID
9178760 .
Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997).
"Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle" . The Journal of Biological Chemistry . 272 (30): 19000–19007.
doi :
10.1074/jbc.272.30.19000 .
PMID
9228082 .
Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology . 27 (9): 2457–2465.
doi :
10.1002/eji.1830270946 .
PMID
9341793 .
S2CID
33397908 .