From Wikipedia, the free encyclopedia
Nicholas Peter Franks
FRS
FRSB (born 14 October 1949) has been Professor of Biophysics and Anaesthetics at
Imperial College London since 1993.
[1] His research focuses on how general
anaesthetics act at the cell and
molecular levels as well as with
neuronal networks .
[2] Franks holds patents on use of
xenon gas as a neuroprotectant
[3] and has published research on the use of the anesthetic properties of xenon.
[4]
He was educated at
Mill Hill School and
King's College London (BSc 1972; PhD 1975).
[5] He was a lecturer in biophysics at Imperial College London from 1977 to 1989 and a reader in
biophysics from 1989 to 1993.
Awards and honours
Along with being made a
Fellow of the Royal Society in 2011,
[6] Franks was elected as a Fellow of the
Academy of Medical Sciences in 2004,
[7] and a Fellow of the
Royal College of Anaesthetists in 2008.
[8] He was awarded the Gold Medal, Royal College of Anaesthetists in 2003,
[9] the Excellence in Research Award,
American Society of Anesthesiologists in 2006
[10] and an Honorary Doctorate from the
University of Montreal in 2011.
[11]
Selected publications
Franks, N.P.; Lieb, W.R. (1978). "Where do general anaesthetics act?". Nature . 274 (5669): 339–342.
doi :
10.1038/274339a0 .
Franks, N.P.; Lieb, W.R. (1979). "The structure of lipid bilayers and the effects of general anaesthetics: An X-ray and neutron diffraction study". Journal of Molecular Biology . 133 (4): 469–500.
doi :
10.1016/0022-2836(79)90403-0 .
Franks, N.P.; Lieb, W.R. (1981). "Is membrane expansion relevant to anaesthesia?". Nature . 292 (5820): 248–251.
doi :
10.1038/292248a0 .
Franks, N.P.; Lieb, W.R. (1982). "Molecular mechanisms of general anaesthesia". Nature . 300 (5892): 487–493.
doi :
10.1038/300487a0 .
Franks, N.P.; Lieb, W.R. (1984). "Do general anaesthetics act by competitive binding to specific receptors?". Nature . 310 (5978): 599–601.
doi :
10.1038/310599a0 .
Franks, N.P.; Lieb, W.R. (1985). "Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects". Nature . 316 (6026): 349–351.
doi :
10.1038/316349a0 .
Franks, N.P.; Lieb, W.R. (1986).
"Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia" . Proceedings of the National Academy of Sciences . 83 (14): 5116–5120.
doi :
10.1073/pnas.83.14.5116 .
PMC
323901 .
Franks, N.P.; Lieb, W.R. (1988). "Volatile general anaesthetics activate a novel neuronal K+ current". Nature . 333 (6174): 662–664.
doi :
10.1038/333662a0 .
Franks, N.P.; Lieb, W.R. (1991). "Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels". Science . 254 (5030): 427–430.
doi :
10.1126/science.1925602 .
Franks, N.P.; Lieb, W.R. (1993).
"Selective actions of volatile general anaesthetics at molecular and cellular levels" . British Journal of Anaesthesia . 71 (1): 65–76.
doi :
10.1093/bja/71.1.65 .
Franks, N.P.; Lieb, W.R. (1994). "Molecular and cellular mechanisms of general anaesthesia". Nature . 367 (6464): 607–614.
doi :
10.1038/367607a0 .
Franks, N.P.; Dickinson, R.; de Sousa, S.L.M.; Hall, A.C.; Lieb, W.R. (1998).
"How does xenon produce anaesthesia?" . Nature . 396 (6709): 324–324.
doi :
10.1038/24525 .
de Sousa, S.L.M.; Dickinson, R.; Lieb, W.R.; Franks, N.P. (2000).
"Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon" . Anesthesiology . 92 (4): 1055–1066.
doi :
10.1097/00000542-200004000-00024 .
Nelson, L.E.; Guo, T.Z.; Lu, J.; Saper, C.B.; Franks, N.P.; Maze, M. (2002). "The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway". Nature Neuroscience . 5 (10): 979–984.
doi :
10.1038/nn913 .
Ma, D.; Wilhelm, S.; Maze, M.; Franks, N.P. (2002).
"Neuroprotective and neurotoxic properties of the 'inert' gas, xenon" . British Journal of Anaesthesia . 89 (5): 739–746.
doi :
10.1093/bja/aef258 .
Franks, N.P. (2008). "General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal". Nature Reviews Neuroscience . 9 (5): 370–386.
doi :
10.1038/nrn2372 .
Zhang, Z.; Ferretti, V.; Güntan, İ.; Moro, A.; Steinberg, E.A.; Ye, Z.; Zecharia, A.Y.; Yu, X.; Vyssotski, A.L.; Brickley, S.G.; Yustos, R.; Pillidge, Z.E.; Harding, E.C.; Wisden, W.; Franks, N.P. (2015).
"Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists" . Nature Neuroscience . 18 (4): 553–561.
doi :
10.1038/nn.3957 .
PMC
4836567 .
References
^
"Professor Nick Franks, FRS" .
Imperial College London . Retrieved 15 March 2016 .
^ Franks, Nicholas (2014).
"The role of K2P channels in anaesthesia and sleep" . European Journal of Physiology . 467 (5): 907–916.
doi :
10.1007/s00424-014-1654-4 .
PMC
4428837 .
PMID
25482669 .
^ Dickinson, R (2007).
"Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology" . Anesthesiology . 107 (5): 756–67.
doi :
10.1097/01.anes.0000287061.77674.71 .
PMID
18073551 .
^ Franks, Nicholas (1998).
"How does xenon produce anaesthesia?" . Nature . 396 (6709): 324.
Bibcode :
1998Natur.396..324F .
doi :
10.1038/24525 .
PMID
9845069 .
S2CID
4415640 .
^ "FRANKS, Prof. Nicholas Peter", Who's Who 2016 , A & C Black, 2016
^
"Nicholas Franks" . The Royal Society. Retrieved 4 January 2024 .
^
"Fellow: Professor Nicholas Franks FRS FMedSci" . Academy of Medical Sciences. Retrieved 4 January 2024 .
^
Criteria for Honours and Prizes (PDF) (Report). Royal College of Anaesthetists. November 2023. p. 14.
^
"The Gold Medal" . Royal College of Anaesthetists. Retrieved 4 January 2024 .
^ Evers, Alex S. (2006).
"Nicholas P. Franks, Ph.D.: Recipient of the 2006 Excellence in Research Award" . Anesthesiology . 105 (4): 649–651.
doi :
10.1097/00000542-200610000-00006 .
^
"Doctorats honoris causa 2011" . Université de Montréal. Retrieved 4 January 2024 .
External links
Neuroprotexeon Scientific Advisory Board
"Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial" , The Lancet Neurology , volume 15 , issue 2, p 145-153, 1 February 2016
"Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury" , Critical Care Medicine , January 2015, volume 43 , issue 1, p 149-158, doi: 10.1097/CCM.0000000000000624