The control region and mtDNA
D-loop are sometimes used synonymously in the literature;[3] specifically the control region includes the D-loop along with adjacent transcription
promoter regions. For this reason, the control region is also known by the
acronym DLP, standing for D-Loop and associated Promoters.[7]
Endurance study
mtDNA control region
haplotypes have been linked with
endurance capacity in human subjects.[8] A 2002 study
sequenced the control region of 55 subjects and compared their haplotype with the increase in
VO2 max after an eight-week
training program. They found that different haplotypes were
significantly linked with the subjects' endurance. It was speculated that this was because the control region affects replication and transcription in the mitochondria.[4][8]
^Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G (October 1999). "Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication". Science. 286 (5440): 774–9.
doi:
10.1126/science.286.5440.774.
PMID10531063.