Middletown is a neighborhood located north of Little Italy ( Downtown San Diego), south of Mission Hills and Hillcrest, east of San Diego International Airport, and west of Bankers Hill. [1] Interstate 5 passes through this neighborhood and San Diego Trolley has one station in this neighborhood. Harper's Topiary Garden is located in the neighborhood as well.
32°44′1″N 117°10′30″W / 32.73361°N 117.17500°W