University of Rochester
California Institute of Technology
Occupation(s)
Geneticist, Stanford B. Ascherman Professor chair of genetics department, Stanford University director of the Center for Genomics and Personalized Medicine
Known for
RNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine
Snyder has co-founded companies in
genetics, genomics, and personalized medicine, including Personalis,[6] a company that develops software to interpret genomes after sequencing; January AI,[7] a health startup; Protometrix;[8] Affomix;[9] and Q Bio.[10]
Snyder has been a principal investigator of the
ENCODE project since its inception in 2003,[11] and co-director of the CIRM Center for Stem Cell Genomics[12] and director of the Center for Genome of Gene Regulation.[13]
Snyder pioneered the use of multi-omic longitudinal profiling to track health.[14][15]
Early life and education
Snyder was born in 1955 and grew up outside of
Pottstown, Pennsylvania.[16][17] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J Roberts High school in Pottstown. He received a BA in chemistry and biology from the
University of Rochester, NY on a scholarship.[18] He went on to receive a PhD in biology from the
California Institute of Technology, where he trained in the laboratory of
Norman Davidson.[19] Snyder completed his postdoctoral training at
Stanford University School of Medicine in the laboratory of
Ronald W. Davis.[19] There he was involved in several projects including establishment of successful cloning of genes using antibodies.[4]
Career
Snyder worked at
Yale University in 1986 as an assistant professor in the department of biology,[18] and was granted tenure in 1994. In 1998, the department of biology split and Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004.[19] His laboratory worked on chromosome segregation and cell polarity, and discovered a number of genes involved in these processes.[20][21]
His laboratory proposed the first models by which
eukaryotes select sites of cell growth.[22][21]
In 2009, Snyder chaired the genetics department at
Stanford University and directed the Center for Genomics and Personalized Medicine.[3][19] Snyder was principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011, was principal investigator for NIH Training Grants in Genomics and Proteomics (first at Yale, now at Stanford) from 2004, and is co-director of the CIRM Center for Stem Cell Genomics[23] and director for the Center for Genome of Gene Regulation.[24] Snyder was president of the US
Human Proteome Organization from 2006 to 2008, and the international
Human Proteome Organization from 2017 to 2018. He currently leads the National Institutes of Health's Encyclopedia of DNA Elements (
ENCODE)'s production center for mapping regulatory regions of the human genome.[25]
Snyder has made contributions to
medicine,
genomics and
biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory at Yale initially focused on studying the genome of the yeast
Saccharomyces cerevisiae, a
eukaryote model organism commonly used in genetics and molecular biology.[30] Later, the lab began to use the same techniques to look at the
human genome.[30]
In 2003, the
Encyclopedia of DNA Elements (ENCODE) project was launched by the US
National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and his lab has contributed a large number of data sets.[19]
Selected publications
Alavi, Arash, et al. Alavi, Arash; Bogu, Gireesh K.; Wang, Meng; Rangan, Ekanath Srihari; Brooks, Andrew W.; Wang, Qiwen; Higgs, Emily; Celli, Alessandra; Mishra, Tejaswini; Metwally, Ahmed A.; Cha, Kexin; Knowles, Peter; Alavi, Amir A.; Bhasin, Rajat; Panchamukhi, Shrinivas; Celis, Diego; Aditya, Tagore; Honkala, Alexander; Rolnik, Benjamin; Hunting, Erika; Dagan-Rosenfeld, Orit; Chauhan, Arshdeep; Li, Jessi W.; Bejikian, Caroline; Krishnan, Vandhana; McGuire, Lettie; Li, Xiao; Bahmani, Amir; Snyder, Michael P. (January 2022).
"Real-time alerting system for COVID-19 and other stress events using wearable data | Nature Medicine". Nature Medicine. 28 (1): 175–184.
doi:
10.1038/s41591-021-01593-2.
PMC8799466.
PMID34845389.. Nature medicine 2021 Nov 29:1-0.
Bahmani, Amir, et al. Bahmani, Amir; Alavi, Arash; Buergel, Thore; Upadhyayula, Sushil; Wang, Qiwen; Ananthakrishnan, Srinath Krishna; Alavi, Amir; Celis, Diego; Gillespie, Dan; Young, Gregory; Xing, Ziye; Nguyen, Minh Hoang Huynh; Haque, Audrey; Mathur, Ankit; Payne, Josh; Mazaheri, Ghazal; Li, Jason Kenichi; Kotipalli, Pramod; Liao, Lisa; Bhasin, Rajat; Cha, Kexin; Rolnik, Benjamin; Celli, Alessandra; Dagan-Rosenfeld, Orit; Higgs, Emily; Zhou, Wenyu; Berry, Camille Lauren; Van Winkle, Katherine Grace; Contrepois, Kévin; Ray, Utsab; Bettinger, Keith; Datta, Somalee; Li, Xiao; Snyder, Michael P. (2021-10-01).
"A scalable, secure, and interoperable platform for deep data-driven health management". Nature Communications. 12 (1). Springer Science and Business Media LLC: 5757.
Bibcode:
2021NatCo..12.5757B.
doi:
10.1038/s41467-021-26040-1.
ISSN2041-1723.
PMC8486823.
PMID34599181.
Mishra, Tejaswini, et al. Mishra, Tejaswini; Wang, Meng; Metwally, Ahmed A.; Bogu, Gireesh K.; Brooks, Andrew W.; Bahmani, Amir; Alavi, Arash; Celli, Alessandra; Higgs, Emily; Dagan-Rosenfeld, Orit; Fay, Bethany; Kirkpatrick, Susan; Kellogg, Ryan; Gibson, Michelle; Wang, Tao; Hunting, Erika M.; Mamic, Petra; Ganz, Ariel B.; Rolnik, Benjamin; Li, Xiao; Snyder, Michael P. (2020-11-18).
"Pre-symptomatic detection of COVID-19 from smartwatch data". Nature Biomedical Engineering. 4 (12). Springer Science and Business Media LLC: 1208–1220.
doi:
10.1038/s41551-020-00640-6.
ISSN2157-846X.
PMC9020268.
PMID33208926.
Kasowski M, Grubert F, Heffelfinger C, Hariharan M, Asabere A, Waszak SM, Habegger L, Rozowsky J, Shi M, Urban AE, … Weissman SM, Gerstein MB, Korbel JO, Snyder M. Kasowski, M.; Grubert, F.; Heffelfinger, C.; Hariharan, M.; Asabere, A.; Waszak, S. M.; Habegger, L.; Rozowsky, J.; Shi, M.; Urban, A. E.; Hong, M. Y.; Karczewski, K. J.; Huber, W.; Weissman, S. M.; Gerstein, M. B.; Korbel, J. O.; Snyder, M. (2010).
"Variation in transcription factor binding among humans - PubMed". Science. 328 (5975): 232–235.
doi:
10.1126/science.1183621.
PMC2938768.
PMID20299548.. Science. 2010. 328(5975): 232-5. Epub 2010. PMID 20299548.