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German neuroendocrinologist (born 1967)
Matthias H. Tschöp (born 7 April 1967) is a German physician and scientist. He is the chief executive officer and scientific director of
Helmholtz Zentrum München , German Research Center for Environmental Health. He is also
Alexander von Humboldt Professor
[1] and chair of metabolic diseases at
Technical University of Munich and serves as an adjunct professor at
Yale University .
Career and research
Tschöp obtained an M.D. from the
Ludwig Maximilian University of Munich (1993), where he worked as a clinician (1994–1998) in neuroendocrinology before accepting a research fellowship at the
Eli Lilly Discovery Research Laboratories (1999–2002) and leading a research team at the
German Institute of Human Nutrition (Potsdam/Nuthetal 2002–2003). He served as a Professor of Endocrinology and Diabetes at the Metabolic Diseases Institute of the
University of Cincinnati (2003–2009), before being named the Arthur Russell Morgan Endowed Chair of Medicine, and Research Director of the Metabolism Center of Excellence for Diabetes and Obesity at the
University of Cincinnati (2009–2011).
[2] He was Research Director of the Helmholtz Diabetes Center and Director of the Institute for Diabetes and Obesity at
Helmholtz Zentrum München (2011–2018).
Early in his career, Tschöp reported on the orexigenic, adipogenic, and metabolic effects of
ghrelin and its secretory control by nutrients, which has had a major influence on human obesity and diabetes research. His corresponding publication in
Nature is among today's most frequently cited metabolism research papers.
[3] It added a fundamental pathway to the current model of body weight and glucose control and established novel drug targets for metabolic diseases. Tschöp went on to further dissect gut-brain communication pathways, based on GI-hormone signaling and lessons from unraveling the molecular underpinnings of gastric bypass surgery.
Together with his close collaborator
Richard DiMarchi (
Indiana University )
[4] he discovered and validated the novel drug class of dual and triple gut hormone co-agonists for the treatment of obesity and diabetes. These new drugs simultaneously target several receptors and reduce body weight and blood sugar with unprecedented efficacy. Several of these compounds are in clinical trials for the treatment of diabetes and obesity and one representative of this drug class, the GIP/GLP1 receptor dual agonist
Tirzepatide (Mounjaro,
Eli Lilly and Company ) was FDA approved for diabetes in 2022. Tschöp and DiMarchi more recently went on to discover and validate another class of drug candidates by engineering peptide to deliver steroid/small molecules to selected cell populations.
[5]
In 2022, Tschöp was a candidate to succeed
Heinz Engl as
rector of the
University of Vienna ; however, he ultimately withdrew his application.
[6] As of January 2023, he is the vice president for health of the
Helmholtz Association of German Research Centers .
[7]
Other activities
Cell , Member of the Advisory Board (since 2020)
[8]
Institute of Metabolism and Systems Research (IMSR),
University of Birmingham , Member of the Scientific Advisory Board
[9]
Awards and recognition
2024: Honorary Doctorate,
Stockholm University
[10]
2023:
Heinrich Wieland Prize
[11]
2023:
Ernst Schering Prize
[12]
2023:
Banting Medal ,
American Diabetes Association
[13]
2022:
European Association for the Study of Diabetes (EASD)-Lilly Centennial Anniversary Prize
[14]
2022: Member of the
Association of American Physicians
2021:
Ernst Jung Prize for Medicine
2021: Berthold Medal of the German Society for Endocrinology
2020: Member of the
European Molecular Biology Organization (EMBO)
2019: C. Ronald Kahn Distinguished Lectureship 2019–2020,
Joslin Diabetes Center
2019: Paul Langerhans Medal
[15]
2018: Carus Prize, City of Schweinfurt
2018: Member of the
Bavarian Academy of Sciences and Humanities
[16]
2017: Carus Medal,
Academy of Sciences Leopoldina
[17]
2017: Charles H. Best Lectureship and Award, University of Toronto
[18]
2017: Hansen Family Award, Bayer Foundations
[19]
2017: Honorary doctorate degree (Dr. h.c.),
University of Leipzig
2017: Rolf Sammet Professorship, Frankfurt University
2017: Outstanding Innovation Award,
Endocrine Society
[20]
2017: Geoffrey Harris Prize
2016: The Victor Mutt Award
2016: European Medal of the Society for Endocrinology
2016: Elected Member,
Academia Europaea
2016: ERC Advanced Grant
2014: Erwin Schrödinger Prize,
Stifterverband Science Award – Erwin Schrödinger Prize
[21]
[22]
2014: Paul Martini Prize, Paul Martini Foundation
[23]
2014: Linda and Jack Gill Distinguished Scientist Award, Linda and Jack Gill Center for Biomolecular Science at Indiana University
[24]
2013: Elected Member, German National
Academy of Sciences Leopoldina
[25]
2012: Werner-Creutzfeld-Award, German Diabetes Society
2012: Alexander von Humboldt Professorship,
Alexander von Humboldt Foundation
2011: Outstanding Scientific Achievement Award,
American Diabetes Association
[26]
2010: NIH/NIDDK 60th Anniversary Scholar Award
[27]
2010: André Mayer Award, Int. Association for the Study of Obesity, IASO
2009: Elected Member, The American Society for Clinical Investigation, ASCI
2007: Scientific Achievement Award,
The Obesity Society , TOS/NAASO
2007: Christina Barz Award of the German Society for Psychiatry, Neurology and Psychosomatic Medicine
2002: Young Investigator Award, European Neuroendocrine Association, ENEA
2001: Schoeller-Junkmann Award of the German Endocrine Society, DGE
2000: Lilly Research Laboratories President's Award
2000: Eli Lilly Endocrine Research Award for Science
References
^
Award winners 2012: Prof. Dr. Matthias Tschöp. humboldt-professur.de. Retrieved 15 January 2014.
^
American Society for Clinical Investigation (ASCI). the-asci.org. Retrieved 22 January 2015.
^ Tschöp, Matthias; Smiley, David L.; Heiman, Mark L. (2000). "Ghrelin induces adiposity in rodents". Nature . 407 (6806): 908–913.
Bibcode :
2000Natur.407..908T .
doi :
10.1038/35038090 .
PMID
11057670 .
S2CID
4564644 .
^ Claiborn, Kathryn (2011).
"Masters of metabolism: Matthias Tschöp and Richard di Marchi " . Journal of Clinical Investigation . 121 (8): 2952.
doi :
10.1172/JCI59886 .
PMC
3148758 .
^ Gruber, Karl (2015).
"Moving towards a more precise treatment of diabetes" . The Lancet Diabetes & Endocrinology . 3 (3): 171.
doi :
10.1016/S2213-8587(15)00010-8 .
PMID
25702247 .
^
Rektorensuche an der Uni Wien: Einziger internationaler Kandidat hat abgesagt
Der Standard , 21 March 2022.
^
Matthias Tschöp New Vice President of the Helmholtz Association. Retrieved 12 April 2023.
^
Advisory Board '
Cell .
^
Scientific Advisory Board Institute of Metabolism and Systems Research (IMSR),
University of Birmingham .
^
Six new honorary doctorates at Stockholm University 2024. Retrieved 29 April 2024
^
Professor Dr Dr h.c. Matthias H. Tschöp, Heinrich Wieland Laureate 2023. Retrieved 27 October 2023.
^
Fight against Obesity and Diabetes: Matthias Tschöp receives Ernst Schering Prize 2023. Retrieved 17 August 2023.
^
Extraordinary Leaders in Diabetes Research, Prevention, and Treatment to be Recognized at the ADA's 83rd Scientific Sessions. Retrieved 24 March 2023.
^
EASD Annual Meeting: Numerous Prizes for DZD Researchers. Retrieved 24 September 2022.
^
Matthias Tschoep receives the highest honor from the German Diabetes Association. www.dzd-ev.de/en. Retrieved 7 June 2019.
^
Matthias Tschöp receives Bavarian honor. tum.de. Retrieved 4 November 2019.
^
DZD Scientist Matthias Tschöp to Receive Carus Medal. dzd-ev.de. Retrieved 7 November 2019.
^
Charles H. Best Lectureship and Award. physiology.utoronto.ca. Retrieved 25 December 2017.
^
"Prestigious award from the Bayer Science & Education Foundation: 2017 Hansen Family Award goes to Professor Jens Brüning and Professor Matthias H. Tschöp" . Archived from
the original on 6 June 2017. Retrieved 25 December 2017.
^ Daniel J. Drucker, MD (Jan 2017).
Meet the 2017 Laureates: Matthias Tschöp, MD. endocrinenews.endocrine.org. Retrieved 25 December 2017.
^
Erwin Schrödinger Preis goes to Helmholtz Zentrum München.
Archived 9 February 2015 at the
Wayback Machine helmholtz-muenchen.de. Retrieved 15 January 2015.
^ Moore, Charles (10 December 2014).
'Unparalleled' Results In Animal Trials Treatment To Cure Adult-onset Diabetes, Obesity. diabetesnewsjournal.com. Retrieved 15 February 2015.
^
Paul Martini Prize: Award for new approaches in the treatment of diabetes and obesity.
Archived 4 March 2016 at the
Wayback Machine paul-martini-stiftung.de. Retrieved 14 January 2015.
^
Gill Symposium honors two neuroscientists for work on the brain's role in regulating metabolism. archive.news.indiana.edu. Retrieved 7 November 2019.
^
Prof. Dr. Matthias Tschöp. leopoldina.org. Retrieved 14 January 2015.
^
"American Diabetes Association Honors UC Researcher With Scientific Achievement Award" .
Archived from the original on 6 January 2018. Retrieved 5 January 2018 .
^
"Tschöp to Receive NIDDK Scholar Award" .
Archived from the original on 6 January 2018. Retrieved 5 January 2018 .
External links
International National Academics Other