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Matthias Lutolf (born in 1973, also known as Matthias Lütolf) is a bio-engineer and a professor at EPFL (École Polytechnique Fédérale de Lausanne) where he leads the Laboratory of Stem Cell Bioengineering. ^{[1] [2]} He is specialised in biomaterials, and in combining stem cell biology and engineering to develop improved organoid models. ^{[3] [4]} In 2021, he became the scientific director for Roche's Institute for Translation Bioengineering in Basel. ^[5]

Career

Lutolf studied materials engineering at ETH Zurich where he graduated in 1998. In 2002, he received his PhD in biomedical engineering from ETH Zurich for his studies on cell-responsive hydrogels for tissue engineering and cell culture, in the group of Jeffrey Hubbell. ^{[6] [7]} He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University, where he worked on novel cell culture approaches for blood and muscle stem cells, so called synthetic niches. ^{[8] [9]} In 2007, he founded his own laboratory at EPFL, where he was promoted to associate professor in 2014 and full professor in 2018. ^[1] From 2014 to 2018, he was director of EPFL's Institute of Bioengineering. ^[10] In June 2021, Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel, Switzerland. ^[5]

Research

Lutolf's laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs. ^[2] Specifically, Lutolf uses bioengineering strategies to guide stem cell-based development to build novel organoids with improved reproducibility and physiological relevance for basic science and in vitro testing of drug candidates. His team has developed approaches to generate organoids in fully controllable 3D matrices, ^{[11] [12]} and has contributed to the understanding of how extrinsic biochemical and physical factors control stem cell fate and organogenesis. ^{[13] [14]} His team has developed concepts based on microfabrication, ^[15] bioprinting, ^[16] and microfluidics ^[17] to improve the reproducibility, size, shape, and function of organoids.

Distinctions

In 2007, Lutolf received the European Young Investigator ( EURYI) Award by the European Science Foundation. ^[18] Since 2018, he is elected as member of the European Molecular Biology Organization (EMBO). ^[19] He serves as associate editor of The Company of Biologists' journal Development. ^[20]

Publications

• Hofer M, Lutolf MP (May 2021). "Engineering organoids". Nature Reviews. Materials. 6 (5): 402–420. Bibcode: 2021NatRM...6..402H. doi: 10.1038/s41578-021-00279-y. PMC  7893133. PMID  33623712.
• Lutolf, M P; Hubbell, J A (January 2005). "Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering". Nature Biotechnology. 23 (1): 47–55. doi: 10.1038/nbt1055. ISSN  1087-0156. PMID  15637621. S2CID  6706970.
• Lutolf, M. P.; Lauer-Fields, J. L.; Schmoekel, H. G.; Metters, A. T.; Weber, F. E.; Fields, G. B.; Hubbell, J. A. (2003-04-09). "Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics". Proceedings of the National Academy of Sciences. 100 (9): 5413–5418. Bibcode: 2003PNAS..100.5413L. doi: 10.1073/pnas.0737381100. ISSN  0027-8424. PMC  154359. PMID  12686696.
• Lutolf, Matthias P.; Gilbert, Penney M.; Blau, Helen M. (November 2009). "Designing materials to direct stem-cell fate". Nature. 462 (7272): 433–441. Bibcode: 2009Natur.462..433L. doi: 10.1038/nature08602. ISSN  0028-0836. PMC  2908011. PMID  19940913.
• Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. (2010-07-15). "Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture". Science. 329 (5995): 1078–1081. Bibcode: 2010Sci...329.1078G. doi: 10.1126/science.1191035. ISSN  0036-8075. PMC  2929271. PMID  20647425.
• Lutolf, Matthias P.; Weber, Franz E.; Schmoekel, Hugo G.; Schense, Jason C.; Kohler, Thomas; Müller, Ralph; Hubbell, Jeffrey A. (2003-04-21). "Repair of bone defects using synthetic mimetics of collagenous extracellular matrices". Nature Biotechnology. 21 (5): 513–518. doi: 10.1038/nbt818. ISSN  1087-0156. PMID  12704396. S2CID  7144594.
• Lutolf, M. P.; Hubbell, J. A. (May 2003). "Synthesis and Physicochemical Characterization of End-Linked Poly(ethylene glycol)-co-peptide Hydrogels Formed by Michael-Type Addition". Biomacromolecules. 4 (3): 713–722. doi: 10.1021/bm025744e. ISSN  1525-7797. PMID  12741789.
• Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (2016-11-16). "Designer matrices for intestinal stem cell and organoid culture". Nature. 539 (7630): 560–564. doi: 10.1038/nature20168. ISSN  0028-0836. PMID  27851739. S2CID  4470849.
• Zhang, H.; Ryu, D.; Wu, Y.; Gariani, K.; Wang, X.; Luan, P.; DAmico, D.; Ropelle, E. R.; Lutolf, M. P.; Aebersold, R.; Schoonjans, K. (2016-06-17). "NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice". Science. 352 (6292): 1436–1443. Bibcode: 2016Sci...352.1436Z. doi: 10.1126/science.aaf2693. ISSN  0036-8075. PMID  27127236.

External links

• Matthias Lütolf publications indexed by Google Scholar
• Website of the Laboratory of Stem Cell Bioengineering

References