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Margaret Ackerman
Alma mater Brandeis University
Massachusetts Institute of Technology
Scientific career
Institutions Massachusetts General Hospital
Dartmouth College
College of Charleston
Thesis Targeting the tight junction : immunotherapy of colon cancer (2010)

Margaret Ackerman is an American engineer who is a professor at Dartmouth College. Ackerman develops high throughput tools to evaluate the antibody response in disease states. She oversees biological and chemical engineering in the Thayer School of Engineering.

Early life and education

Ackerman was an undergraduate student at Brandeis University where she studied biochemistry.[ citation needed] After earning her doctorate, she spent one year at the College of Charleston, where she taught chemistry. In 2004 she moved to the Massachusetts Institute of Technology for doctoral research. Her doctorate evaluated immunotherapy in the treatment of colorectal cancer. [1] She was appointed a postdoctoral fellow at the Massachusetts General Hospital in 2010.[ citation needed]

Research and career

In 2011, Ackerman joined Dartmouth College as an Assistant Professor. [2] She was promoted to Professor in 2019.[ citation needed] Her research considers the development of novel vaccines. [3] Amongst these, she has worked on the development of vaccines to protect against HIV [4] [5] and Herpes simplex virus. [6] Her vaccines look to make use of the innate immune system, the early response system that protects us from pathogens until our adaptive immune system responds. [7] The ability of antibodies to recruit an innate immune response is known as the effector function. [7] Ackerman has explored ways to engineer Regulatory T cells to target the fibrils that form in the neural tissue of people suffering from Parkinson's disease. [8] She was awarded a Faculty Mentor Award in 2016. [9]

During the COVID-19 pandemic, Ackerman studied the levels of antibodies in recovering COVID-19 patients. [10] Specifically, she studied the levels of Immunoglobulin A (IgA) antibodies in their mucus. [11] Her research identified that people who suffered from more mild cases of COVID-19 displayed increased levels of IgA. She also showed that there was an anti-correlation between levels of IgA and IgG, i.e., people with high IgA levels had low IgG levels. [11]

Selected publications

  • Margaret E Ackerman; Max Crispin; Xiaojie Yu; et al. (8 April 2013). "Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity". Journal of Clinical Investigation. 123 (5): 2183–2192. doi: 10.1172/JCI65708. ISSN  0021-9738. PMC  3637034. PMID  23563315. S2CID  7515592. Wikidata  Q36797342.
  • Margaret E Ackerman; Brian Moldt; Richard T Wyatt; et al. (27 December 2010). "A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples". Journal of Immunological Methods. 366 (1–2): 8–19. doi: 10.1016/J.JIM.2010.12.016. ISSN  0022-1759. PMC  3050993. PMID  21192942. S2CID  33747259. Wikidata  Q30498394. (erratum)
  • Dan H Barouch; Galit Alter; Thomas Broge; et al. (2 July 2015). "Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys". Science. 349 (6245): 320–324. doi: 10.1126/SCIENCE.AAB3886. ISSN  0036-8075. PMC  4653134. PMID  26138104. Wikidata  Q36300153.

Books

References

  1. ^ Ackerman, Margaret E (2010). Targeting the tight junction: immunotherapy of colon cancer (Thesis). OCLC  720986513.
  2. ^ "Professors Ackerman and Halter Receive Faculty Mentor Awards". Dartmouth Engineering. Retrieved 2021-12-11.
  3. ^ Hamzelou, Jessica. "Vaccine research gets a shot in the arm". New Scientist. Retrieved 2021-12-11.
  4. ^ "Neonatal Herpes Acquired From Mom Can Be Fatal". www.precisionvaccinations.com. Retrieved 2021-12-11.
  5. ^ "Thayer prof. works on HIV vaccine". Dartmouth Engineering. Retrieved 2021-12-11.
  6. ^ "A Mother Lode of Protection". hms.harvard.edu. 17 April 2019. Retrieved 2021-12-11.
  7. ^ a b "Ragon and Dartmouth collaborate to tailor new vaccine approach…". Dartmouth Engineering. Retrieved 2021-12-11.
  8. ^ "SYNERGY Announces 2017 Translational Pilot Grant Awards". Dartmouth Engineering. Retrieved 2021-12-11.
  9. ^ "Professors Ackerman and Halter Receive Faculty Mentor Awards". Dartmouth Engineering. Retrieved 2021-12-11.
  10. ^ "Rebooting Research, Phase One". Dartmouth Engineering. Retrieved 2021-12-11.
  11. ^ a b "Milder Cases of COVID-19 Linked to IgA Antibodies". Dartmouth Engineering. Retrieved 2021-12-11.
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