Malonoben (also known as tyrphostin A9, SF-6847, GCP5126, and AG-17) is an
uncoupling agent/
protonophore.[1][2] As of 1974 when it was discovered, it was considered the most powerful agent of this type, with a potency over 1800 times that of
2,4-dinitrophenol - the prototypical uncoupling agent - and about 3 times the effectiveness of 5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide.[3]
References
^Terada, H.; Fukui, Y.; Shinohara, Y.; Ju-ichi, M. (1988-03-30). "Unique action of a modified weakly acidic uncoupler without an acidic group, methylated SF 6847, as an inhibitor of oxidative phosphorylation with no uncoupling activity: possible identity of uncoupler binding protein". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 933 (1): 193–199.
doi:
10.1016/0005-2728(88)90070-9.
PMID2894856.
^Terada, H.; VAN Dam, K. (1975-06-17). "On the stoichiometry between uncouplers of oxidative phosphorylation and respiratory chains. The catalytic action of SF 6847 (3,5-di-tert-butyl-4-hydroxy-benzylidenemalononitrile)". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 387 (3): 507–518.
doi:
10.1016/0005-2728(75)90089-4.
PMID1138887.
^Terada, H. (November 7, 1974). "Some biochemical and physicochemical properties of the potent uncoupler SF 6847 (3,5-di-tert-butyl-4-hydroxybenzylidenemalononitrile)". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 387 (3): 519–532.
doi:
10.1016/0005-2728(75)90090-0.
PMID237542.